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This results in the enhancement of immunotherapy. Immunotherapy has been identified as an effective treatment option for various types of cancer. However, it has become increasingly evident that the benefits of immunotherapy are less than expected, as recognized by the fact that only a small percentage of cancer patients respond positively to it. The structurally and functionally abnormal tumor vasculature, a characteristic feature of most solid tumors, contributes to the creation of an immunosuppressive microenvironment. This poses a significant challenge for immunotherapy. On the other hand, tumor antiangiogenic therapy could remodel the immune microenvironment by interfering with the function of immune cells, improving the anti\u2010tumor efficacy. In this review, we primarily discuss the current research progress of anti\u2010tumor angiogenesis drugs and the effects of tumor vasculature on immune cells in the tumor microenvironment (TME). 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