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Although their dysregulation is well described in solid tumors, little is known about their role in hematologic malignancies. We investigated the expression of ten RHO GTPase genes in bone marrow samples from patients with acute myeloid leukemia (AML) and myelodysplastic neoplasms (MDS) and analyzed TCGA AML data for prognostic associations.\n                    <jats:italic>RHOBTB2<\/jats:italic>\n                    ,\n                    <jats:italic>RND2<\/jats:italic>\n                    , and\n                    <jats:italic>RHOQ<\/jats:italic>\n                    were differentially expressed compared with healthy controls.\n                    <jats:italic>RHOBTB2<\/jats:italic>\n                    was elevated in both MDS and AML and associated with inferior overall and disease\u2010free survival, including in intermediate\u2010risk AML. Our findings reveal distinct dysregulation patterns of RHO GTPases in myeloid malignancies and confirm\n                    <jats:italic>RHOBTB2<\/jats:italic>\n                    as a candidate prognostic marker in AML with a potential oncogenic role. These data support further investigation into the functional roles of RHO GTPases in leukemogenesis and their utility as emerging biomarkers in hematologic cancers.\n                  <\/jats:p>","DOI":"10.1002\/cam4.71770","type":"journal-article","created":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T02:00:47Z","timestamp":1775181647000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Profiling Ten\n                    <scp>RHO GTPases<\/scp>\n                    in Myeloid Malignancies Reveals Distinct Expression Patterns and Prognostic Associations"],"prefix":"10.1002","volume":"15","author":[{"given":"Beatriz","family":"de Almeida Rodrigues","sequence":"first","affiliation":[{"name":"Department of Clinical and Experimental Oncology Federal University of S\u00e3o Paulo (UNIFESP)  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciana Bueno","family":"de 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