{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T05:49:40Z","timestamp":1777009780944,"version":"3.51.4"},"reference-count":57,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T00:00:00Z","timestamp":1775347200000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/W026961\/1"],"award-info":[{"award-number":["MR\/W026961\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012041","name":"Versus Arthritis","doi-asserted-by":"publisher","award":["21530, 21812"],"award-info":[{"award-number":["21530, 21812"]}],"id":[{"id":"10.13039\/501100012041","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018952","name":"Birmingham Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018952","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies because of its typically late diagnosis and limited treatment options, with surgical resection being the primary intervention. Emerging studies have consistently reported associations between PDAC and metabolic dysfunctions, including obesity, chronic inflammation, and diabetes. In this study, we investigated the molecular interplay between PDAC\u2010associated genes and metabolic disorder pathways.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analysed publicly available bulk RNA\u2010Seq datasets from human and murine adipose tissues, complemented by single\u2010cell RNA\u2010Seq data from advanced\u2010stage PDAC. A set of key genes, ITGAM, PECAM1, CCL5, STAT1, STAT2, and CD44, was examined for expression patterns across datasets. Unsupervised clustering techniques were applied to single\u2010cell data to identify transcriptionally distinct populations. Functional analyses were conducted using KEGG pathway enrichment and STRING\u2010based protein\u2013protein interaction networks. To experimentally validate transcriptomic findings, we performed \u0394CT\u2010based quantitative PCR (qPCR) on human adipose tissue samples.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Gene expression analyses revealed significantly high expression of PDAC\u2010associated markers in both obese human and mouse models. Specific single\u2010cell clusters demonstrated transcriptional profiles linked to metabolic dysregulation in PDAC. Enrichment and network analyses implicated diabetic complication pathways and inflammatory signalling cascades. Experimental validation confirmed that genes such as ITGAM, CCL5, CXCL10, STAT1, and STAT2 were significantly upregulated in obese individuals compared to lean controls, underscoring a potential immunometabolic axis in PDAC pathophysiology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings highlight a strong association between the upregulation of PDAC recurrence genes and the activation of metabolic pathways linked to obesity, diabetes, and inflammation. The consistent expression patterns across species suggest potential for developing targeted therapies to inhibit these metabolic pathways post\u2010pancreatic cancer resection, potentially reducing fatality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71775","type":"journal-article","created":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T03:21:42Z","timestamp":1775445702000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Linking Targeted Pancreatic Cancer Genes With Metabolic Disorders: A Cross\u2010Species Translational Pathway"],"prefix":"10.1002","volume":"15","author":[{"given":"Dipanwita","family":"Nath","sequence":"first","affiliation":[{"name":"Department of Cancer and Genomic Sciences School of Medical Sciences, College of Medicine and Health, University of Birmingham  Birmingham 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