{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T05:49:17Z","timestamp":1777009757671,"version":"3.51.4"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T00:00:00Z","timestamp":1775347200000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["88887.568762\/2020\u201000"],"award-info":[{"award-number":["88887.568762\/2020\u201000"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Giant Cell Lesions exhibit variable aggressive clinical behavior. Understanding the molecular mechanisms of these lesions can facilitate a more personalized and effective therapeutic approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>The acetylation of Histone H3 at Lysine 9 (H3K9ac) and the expression of Inhibitor of Growth Protein 5 (ING5) were evaluated in 19 cases of Peripheral Giant Cell Granuloma (PGCG), 19 cases of non\u2010aggressive Central Giant Cell Granuloma (CGCG), 19 cases of aggressive CGCG, and 19 cases of Giant Cell Tumor of Bone (GCTB), totaling 76 cases of Giant Cell Lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      H3K9 hyperacetylation was found in aggressive Giant Cell Lesions compared to non\u2010aggressive lesions (\n                      <jats:italic>p\u2009&lt;<\/jats:italic>\n                      \u20090.05). Aggressive Giant Cell Lesions also show higher ING5 expression in multinucleated giant cells and cannibalistic multinucleated giant cells compared to non\u2010aggressive lesions (\n                      <jats:italic>p\u2009&lt;<\/jats:italic>\n                      \u20090.05). There was no difference in the levels of H3K9ac and ING5 between aggressive Central Giant Cell Granuloma and Giant Cell Tumor of Bone (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05). H3K9ac and ING5 were associated with aggressive characteristics in the CGCG (\n                      <jats:italic>p\u2009&lt;<\/jats:italic>\n                      \u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>H3K9 hyperacetylation highlights the significance of this epigenetic event in the aggressiveness of Giant Cell Lesions and may indicate their potential for aggressive behavior, thereby providing information to improve treatment strategies, particularly for Central Giant Cell Granuloma. Understanding the CGCG's clinical behavior is essential for determining the therapeutic modality and avoiding long\u2010term post\u2010treatment sequelae.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71785","type":"journal-article","created":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T01:20:37Z","timestamp":1775438437000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Histone 3 Hyperacetylation and the Aggressive Behavior of Giant Cell Lesions"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3103-3588","authenticated-orcid":false,"given":"Caio C\u00e9sar","family":"da Silva Barros","sequence":"first","affiliation":[{"name":"Epithelial Biology Laboratory, Department of Periodontics and Oral Medicine University of Michigan School of Dentistry  Ann Arbor Michigan USA"},{"name":"Postgraduate Program in Dental Sciences, Oral Pathology and Medicine, Department of Dentistry Federal University of Rio Grande Do Norte  Natal RN Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2128-0147","authenticated-orcid":false,"given":"\u00c9ricka Janine Dantas","family":"da Silveira","sequence":"additional","affiliation":[{"name":"Epithelial Biology Laboratory, Department of Periodontics and Oral Medicine University of Michigan School of Dentistry  Ann Arbor Michigan USA"},{"name":"Postgraduate Program in Dental Sciences, Oral Pathology and Medicine, Department of Dentistry Federal University of Rio Grande Do Norte  Natal RN Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1rcia Cristina","family":"da Costa Miguel","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Dental Sciences, Oral Pathology and Medicine, Department of Dentistry Federal University of Rio Grande Do Norte  Natal RN Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5358-612X","authenticated-orcid":false,"given":"Rogerio Moraes","family":"Castilho","sequence":"additional","affiliation":[{"name":"Epithelial Biology Laboratory, Department of Periodontics and Oral Medicine University of Michigan School of Dentistry  Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6782-3429","authenticated-orcid":false,"given":"Cristiane Helena","family":"Squarize","sequence":"additional","affiliation":[{"name":"Epithelial Biology Laboratory, Department of Periodontics and Oral Medicine University of Michigan School of Dentistry  Ann Arbor Michigan 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