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Here, we combined transcriptomic profiling with functional validation to identify claudin\u20102 (CLDN2) as a critical mediator of Art B's anticancer effects in NSCLC.\n                    <jats:italic>CLDN2<\/jats:italic>\n                    , significantly upregulated in NSCLC tissues versus paired normal tissues, promoted tumor cell proliferation and cisplatin resistance by upregulating multidrug resistance\u2010associated protein 2 (MRP2). Mechanistically, miR\u2010194\u20103p directly binds to two conserved sites (nt 358\u2013365 and 1232\u20131238) within the\n                    <jats:italic>CLDN2<\/jats:italic>\n                    3\u2032 UTR, suppressing its expression via mRNA degradation and translational inhibition, thereby attenuating proliferation and resensitizing cells to cisplatin. Importantly, Art B exerted antitumor effects by upregulating\n                    <jats:italic>miR\u2010194\u20103p<\/jats:italic>\n                    , which subsequently inhibited\n                    <jats:italic>CLDN2<\/jats:italic>\n                    . This study not only elucidates a previously unrecognized mechanism for overcoming chemoresistance but also nominates CLDN2 as a prognostic biomarker, offering a promising therapeutic strategy that could benefit NSCLC patients facing treatment failure.\n                  <\/jats:p>","DOI":"10.1002\/cam4.71796","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T03:18:40Z","timestamp":1776223120000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Arteannuin B Inhibits\n                    <scp>NSCLC<\/scp>\n                    Cells via Regulating\n                    <scp>miR<\/scp>\n                    \u2010194\u20103p\/\n                    <scp>\n                      <i>CLDN2<\/i>\n                    <\/scp>\n                    Axis"],"prefix":"10.1002","volume":"15","author":[{"given":"Ting\u2010Sha","family":"He","sequence":"first","affiliation":[{"name":"Department of Pharmacology, College of Pharmacy Jinan University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong\u2010Hui","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, College of Pharmacy Jinan University  Guangzhou China"},{"name":"Biotechnological Institute of Chinese Materia Medica Jinan University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, College of Pharmacy Jinan University  Guangzhou China"},{"name":"Biotechnological Institute of Chinese Materia Medica Jinan University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Chinese Materia Medica, College of Pharmacy Jinan University  Guangzhou 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