{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T22:20:58Z","timestamp":1782080458330,"version":"3.54.5"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T00:00:00Z","timestamp":1776038400000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,4]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n The optimal consolidation strategy following high\u2010dose methotrexate (MTX)\u2013based induction in primary central nervous system lymphoma (PCNSL) remains controversial. This study compared real\u2010world outcomes of different consolidation modalities in patients responsive to rituximab, MTX, vincristine, and procarbazine (R\u2010MVP) induction chemotherapy.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We retrospectively analyzed 296 newly diagnosed PCNSL patients treated with R\u2010MVP between 2008 and 2023. Among 290 evaluable patients, the overall response rate (ORR) was assessed, and survival outcomes were evaluated by Kaplan\u2013Meier and Cox regression analyses. Propensity score matching (PSM) was performed to compare autologous stem\u2010cell transplantation (ASCT) and whole\u2010brain radiotherapy (WBRT).<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The ORR was 89.7%, with 71.7% achieving complete response (CR) or complete response unconfirmed (CRu) and 17.9% partial response (PR). Of 260 responders, 190 received consolidation: WBRT (40.8%), ASCT (20.0%), or non\u2010myelosuppressive chemotherapy (NMC; 12.3%). After a median follow\u2010up of 45.3\u2009months, median progression\u2010free survival (PFS) and overall survival (OS) for responders were 65.8 (95% CI 50.7\u201380.8) and 84.6\u2009months (95% CI 66.5\u2013102.7), respectively. ASCT yielded the most favorable survival (median PFS not reached), followed by WBRT (70.8\u2009months), whereas NMC and no\u2010consolidation groups showed significantly inferior PFS (22.9 and 40.1\u2009months,\n p<\/jats:italic>\n \u2009<\u20090.001). OS showed a similar trend (\n p<\/jats:italic>\n \u2009=\u20090.006). On multivariable analysis, elevated LDH and consolidation type were independent predictors of PFS, whereas age and consolidation type were significant prognostic factors for OS. In the PSM cohort (ASCT vs. WBRT,\n n<\/jats:italic>\n \u2009=\u200952 each), median PFS was not reached for ASCT versus 90.0\u2009months for WBRT (\n p<\/jats:italic>\n \u2009=\u20090.050); OS was not reached versus 97.9\u2009months (\n p<\/jats:italic>\n \u2009=\u20090.160).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n ASCT was associated with the most durable survival among consolidation strategies after R\u2010MVP induction. These findings, derived from a large real\u2010world, multi\u2010institutional cohort, support ASCT as the preferred consolidation for eligible patients while underscoring the heterogeneity of current practice and the need for prospective validation.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/cam4.71806","type":"journal-article","created":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T11:48:12Z","timestamp":1776080892000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparative Outcomes of Consolidation Strategies After R\u2010\n MVP<\/scp>\n Induction in Primary Diffuse Large B\u2010Cell Lymphoma of the Central Nervous System"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8529-0232","authenticated-orcid":false,"given":"Sang\u2010A","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Seoul National University Bundang Hospital, Seoul National University College of Medicine Seongnam Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Sun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine CHA Bundang Medical Center, CHA University School of Medicine Seongnam Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Yun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Bundang Hospital, Seoul National University College of Medicine Seongnam Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joo Ho","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Seoul National University Hospital, Cancer Research Institute, Seoul National University College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keun\u2010Yong","family":"Eom","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Seoul National University Bundang Hospital, Seoul National University College of Medicine Seongnam Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2350-9876","authenticated-orcid":false,"given":"Chul\u2010Kee","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Seoul National University Hospital, Seoul National University College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chae\u2010Yong","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Seoul National University Bundang Hospital, Seoul National University College of Medicine Seongnam Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dae Seog","family":"Heo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Hospital, Seoul National University College of Medicine Seoul Republic of Korea"},{"name":"Department of Genomic Medicine Seoul National University Hospital Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong\u2010Ok","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Bundang Hospital, Seoul National University College of Medicine Seongnam Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6145-4426","authenticated-orcid":false,"given":"Tae Min","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Hospital, Seoul National University College of Medicine Seoul Republic of Korea"},{"name":"Department of Genomic Medicine Seoul National University Hospital Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2011.357"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2020.847"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.03.036"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70229-1"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.12.5062"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.72.7602"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/now033"},{"key":"e_1_2_10_9_1","unstructured":"National Comprehensive Cancer Network (NCCN) \u201cNCCN Guidelines for Primary CNS Lymphoma 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4.2024."},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2023.11.010"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2024013780"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2024.115068"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.21037\/aol-20-47"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.50.4910"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(17)30174-6"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-022-01582-5"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.18.00306"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.00491"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2023011657"},{"issue":"2","key":"e_1_2_10_20_1","first-page":"LBA\u20133\u2013LBA\u20133","article-title":"Effects on Survival of Non\u2010Myeloablative Chemoimmunotherapy Compared to High\u2010Dose Chemotherapy Followed by Autologous Stem Cell Transplantation (HDC\u2010ASCT) as Consolidation Therapy in Patients With Primary CNS Lymphoma\u2014Results of an International Randomized Phase III Trial (MATRix\/IELSG43)","volume":"140","author":"Illerhaus G.","year":"2022","journal-title":"Blood"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/oncolo\/oyac190"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2022.11.002"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2023020911"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctro.2022.12.002"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13014-023-02251-2"}],"container-title":["Cancer 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