{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:32:44Z","timestamp":1791347564704,"version":"4.3.1"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370192"],"award-info":[{"award-number":["82370192"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U24A20680"],"award-info":[{"award-number":["U24A20680"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study evaluated the efficacy and safety of mecapegfilgrastim for preventing immunochemotherapy\u2010induced neutropenia in treatment\u2010naive patients with diffuse large B\u2010cell lymphoma (DLBCL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this open\u2010label, multicenter exploratory trial, patients were randomized in a 2:1 ratio to receive mecapegfilgrastim or no prophylaxis. All participants received 4 cycles of R\u2010CHOP or R\u2010CHOP\u2010like regimens. The primary endpoint was the incidence of grade \u2265\u20093 neutropenia during cycle 1.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Between October 2021 and June 2024, 42 patients were enrolled (mecapegfilgrastim:\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200928; control:\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200914). Grade \u2265\u20093 neutropenia in cycle 1 occurred in 32.14% of the mecapegfilgrastim group versus 64.29% in the control group. Across all cycles, mecapegfilgrastim consistently reduced grade \u2265\u20093 neutropenia; nadir neutrophil counts were higher and the need for short\u2010acting granulocyte colony\u2010stimulating factor was lower in the mecapegfilgrastim group (all nominal\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2264\u20090.05). No cases of febrile neutropenia occurred in the mecapegfilgrastim group, compared to one case in the control group. Objective response rates were 75.0% (95% CI: 55.1, 89.3) and 57.1% (95% CI: 28.9, 82.3), respectively (nominal\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.298). Mecapegfilgrastim reduced the incidence of grade \u2265\u20093 neutropenia regardless of treatment response. Grade \u2265\u20093 treatment\u2010emergent adverse events (TEAEs) occurred in 42.9% of the mecapegfilgrastim group and 92.9% of controls; serious TEAEs were reported in 7.1% of patients in both groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Mecapegfilgrastim demonstrated a favorable safety profile and potential efficacy in reducing the incidence and severity of neutropenia in DLBCL patients receiving R\u2010CHOP or R\u2010CHOP\u2010like regimens. These findings may support its prophylactic use in this population and warrant validation in larger trials.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/chictr.org.cn\">chictr.org.cn<\/jats:ext-link>\n                      : ChiCTR2100048196. Registered on July 4, 2021\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71821","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T17:30:17Z","timestamp":1777051817000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Mecapegfilgrastim for Prophylaxis of Immunochemotherapy\u2010Induced Neutropenia in Patients With Diffuse Large B\u2010Cell Lymphoma: A Multicenter Pilot Trial"],"prefix":"10.1002","volume":"15","author":[{"given":"Jie","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Hematology Institute of Hematology, and Center for High Altitude Medicine, West China Hospital, Sichuan University  Chengdu Sichuan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematology Institute of Hematology, and Center for High Altitude Medicine, West China Hospital, Sichuan University  Chengdu Sichuan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaochu","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Hematology West China Xiamen Hospital of Sichuan University  Xiamen Fujian Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4103-6304","authenticated-orcid":false,"given":"Yong","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Hematology Institute of Hematology, and Center for High Altitude Medicine, West China Hospital, Sichuan University  Chengdu Sichuan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1174-4078","authenticated-orcid":false,"given":"Hongbing","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Hematology Institute of Hematology, and Center for High Altitude Medicine, West China Hospital, Sichuan University  Chengdu Sichuan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3069-2787","authenticated-orcid":false,"given":"Bing","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Hematology Institute of Hematology, and Center for High Altitude Medicine, West China Hospital, Sichuan University  Chengdu Sichuan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenlu","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Hematology Institute of Hematology, and Center for High Altitude Medicine, West China Hospital, Sichuan University  Chengdu Sichuan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7772-8011","authenticated-orcid":false,"given":"Kai","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of 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