{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T15:04:58Z","timestamp":1784819098359,"version":"3.55.0"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:00:00Z","timestamp":1776124800000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Cancer remains a leading cause of global morbidity and mortality, underscoring the need for accessible biomarkers for early detection and risk stratification. The red blood cell distribution width\u2010to\u2010albumin ratio (RAR) integrates inflammation and nutritional markers often dysregulated in cancer. We evaluated RAR's association with a recent diagnosis (\u2264\u20091\u2009year) of breast, colorectal, lung, and prostate cancer in a representative US population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using National Health and Nutrition Examination Survey data (2005\u20132018), we conducted a cross\u2010sectional analysis of adults with recent diagnoses (\u2264\u20091\u2009year) of a single primary cancer. Propensity score matching balanced cases and cancer\u2010free comparisons by age, sex, and race. Weighted logistic regression assessed associations between a 1\u2010unit RAR (%dL\/g) increase and cancer presence, reporting adjusted odds ratios (ORs) with 95% confidence intervals (CIs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The analysis included 48 breast, 31 colorectal, 19 lung, and 77 prostate cancer cases, along with their matched comparisons. A 1%\u2009dL\/g increase in RAR was significantly associated with higher odds of breast (adjusted OR 1.62, 95% CI 1.17\u20132.24), colorectal (adjusted OR 1.56, 95% CI 1.01\u20132.40), and lung cancer (adjusted OR 1.95, 95% CI 1.44\u20132.66). No significant association was observed for prostate cancer (adjusted OR 1.05, 95% CI 0.69\u20131.59).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>RAR is significantly associated with a recent diagnosis of breast, colorectal, and lung cancers, but not prostate cancer. These findings suggest RAR may reflect cancer\u2010associated systemic alterations, warranting further prospective study to validate its clinical applicability.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71839","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T03:45:02Z","timestamp":1776224702000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Association Between Red Blood Cell Distribution Width\u2010To\u2010Albumin Ratio and Breast, Colorectal, Lung, and Prostate Cancers"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2086-0425","authenticated-orcid":false,"given":"Parham","family":"Habibzadeh","sequence":"first","affiliation":[{"name":"Department of Medicine University of Pittsburgh Medical Center  Pittsburgh Pennsylvania USA"},{"name":"School of Computing and Information University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Sorkin","sequence":"additional","affiliation":[{"name":"Department of Epidemiology University of Maryland School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"Hsu","sequence":"additional","affiliation":[{"name":"UPMC Hillman Cancer Center, Division of Malignant Hematology and Oncology, University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,14]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885\u2010025\u201015165\u2010x"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010025\u201015309\u2010w"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2009.55"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/10408363.2014.992064"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jpen.1451"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2018.04.014"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2018.04.016"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.1019502"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd\u201023\u20101696"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJGM.S393393"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.13213"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.24423"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2021.1871925"},{"key":"e_1_2_13_15_1","unstructured":"National 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