{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T13:42:48Z","timestamp":1784122968431,"version":"3.55.0"},"reference-count":74,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T00:00:00Z","timestamp":1776816000000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,4]]},"abstract":"ABSTRACT<\/jats:title>\n \n Purpose<\/jats:title>\n The main objective of the Sarco\u2010Detect study was to evaluate diagnostic tools\u2014bioelectrical impedance analysis (BIA) and handgrip strength (HGS)\u2014for determining sarcopenia compared with computed tomography (CT). The secondary aim was to evaluate the SARC\u2010F questionnaire as a screening tool and to investigate the impact of muscle loss on quality of life, fatigue, HGS, and the association between previous physical activity and muscle loss.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n The study was conducted at the University Cancer Center Schleswig\u2010Holstein. To assess muscle mass status, BIA and HGS were measured in patients with cancer and compared with CT. Additionally, EORTC QLQ\u2010C30, FACIT\u2010Fatigue Scale, BSA, and SARC\u2010F questionnaires were administered.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n One hundred thirty one patients were recruited. Fourteen patients showed a CT\u2010SMI below the reference values by Van der Werf et\u00a0al. (2018). Thirteen patients showed reduced HGS. CT\u2010SMI and HGS correlated significantly (\n r<\/jats:italic>\n \u2009=\u20090.492,\n p<\/jats:italic>\n \u2009=\u20090.001). The phase angle of the BIA correlated significantly with CT\u2010SMI (\n r<\/jats:italic>\n \u2009=\u20090.441,\n p<\/jats:italic>\n \u2009=\u20090.001) and HGS (\n r<\/jats:italic>\n \u2009=\u20090.493,\n p<\/jats:italic>\n \u2009=\u20090.001). Patients with reduced HGS presented significantly higher appetite loss compared with patients with preserved HGS. Patients with preserved HGS showed a higher quality of life than patients with reduced HGS. FACIT\u2010Fatigue scores differed significantly between patients with reduced HGS and those with preserved HGS (\n F<\/jats:italic>\n (1, 104)\u2009=\u20093.991,\n p<\/jats:italic>\n \u2009=\u20090.048;\n U<\/jats:italic>\n \u2009=\u2009321.000,\n Z<\/jats:italic>\n \u2009=\u2009\u22122.088,\n p<\/jats:italic>\n \u2009=\u20090.037). Activity index correlated moderately with fatigue symptoms and quality of life. The SARC\u2010F showed a sensitivity of 18.8% and specificity of 96.6% for HGS, and a sensitivity of 31.3% and specificity of 90.7% for CT\u2010SMI.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n CT\u2010SMI and HGS correlated positively and significantly. The BIA phase angle correlated with CT\u2010SMI and HGS. Reduced HGS is associated with increased appetite loss, higher fatigue, and lower quality of life. SARC\u2010F questionnaire appears suitable for identifying patients without sarcopenia.<\/jats:p>\n <\/jats:sec>\n \n Trial Registration<\/jats:title>\n German Clinical Trials Register: DRKS00035258<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/cam4.71842","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T13:48:17Z","timestamp":1776865697000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Sarcopenia in Oncological Patients Diagnostics, Screening, and Impact on Quality of Life, Fatigue, Handgrip Strength, and Physical Activity (Sarco\u2010Detect Study)"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1053-1262","authenticated-orcid":false,"given":"Friederike","family":"Hilpert","sequence":"first","affiliation":[{"name":"Universit\u00e4res Cancer Center Schleswig\u2010Holstein (UCCSH) Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Jochem","sequence":"additional","affiliation":[{"name":"Universit\u00e4res Cancer Center Schleswig\u2010Holstein (UCCSH) Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lea Feline","family":"Kraack","sequence":"additional","affiliation":[{"name":"Universit\u00e4res Cancer Center Schleswig\u2010Holstein (UCCSH) Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilka","family":"Ratjen","sequence":"additional","affiliation":[{"name":"Universit\u00e4res Cancer Center Schleswig\u2010Holstein (UCCSH) Kiel Germany"},{"name":"Universit\u00e4tsklinikum Schleswig\u2010Holstein Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friederike","family":"St\u00f6lzel","sequence":"additional","affiliation":[{"name":"Universit\u00e4res Cancer Center Schleswig\u2010Holstein (UCCSH) Kiel Germany"},{"name":"Universit\u00e4tsklinikum Schleswig\u2010Holstein Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thore","family":"Wulff","sequence":"additional","affiliation":[{"name":"Universit\u00e4res Cancer Center Schleswig\u2010Holstein (UCCSH) Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Letsch","sequence":"additional","affiliation":[{"name":"Universit\u00e4res Cancer Center Schleswig\u2010Holstein (UCCSH) Kiel Germany"},{"name":"Universit\u00e4tsklinikum Schleswig\u2010Holstein Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorsten","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Universit\u00e4res Cancer Center Schleswig\u2010Holstein (UCCSH) Kiel Germany"},{"name":"Universit\u00e4tsklinikum Schleswig\u2010Holstein Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,22]]},"reference":[{"issue":"1","key":"e_1_2_12_2_1","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1093\/ageing\/afy169","article-title":"Sarcopenia: Revised European Consensus on Definition and Diagnosis","volume":"48","author":"Cruz\u2010Jentoft A. 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