{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T05:48:39Z","timestamp":1777009719687,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Hereditary breast and ovarian cancer (HBOC) syndromes are strongly associated with germline pathogenic variants. While genetic testing historically focused on BRCA1\/2, multigene panels have revealed clinically relevant variants in numerous non\u2010BRCA genes. However, data on the spectrum and prevalence of these variants remain limited in Argentina, particularly in regions with distinctive admixture patterns. This study aimed to determine the frequency and spectrum of pathogenic and likely pathogenic variants (P\/LPVs) in non\u2010BRCA genes among patients with a personal and\/or family history of breast or ovarian cancer evaluated in C\u00f3rdoba, Argentina. We conducted a retrospective analysis of 283 individuals tested within the Oncogenetics Program at Hospital Privado Universitario de C\u00f3rdoba between 2016 and 2022 using multigene next\u2010generation sequencing panels and Sanger sequencing according to contemporary clinical criteria. P\/LPVs were identified in 85 individuals (30.0%, 95% CI: 24.7\u201335.8), with non\u2010BRCA genes accounting for 32 P\/LPVs (11.3%, 95% CI: 7.9\u201315.6 of the cohort). The most prevalent non\u2010BRCA genes were PALB2 (4.59%, 95% CI: 2.5\u20137.7) and CHEK2 (2.47%, 95% CI: 1.0\u20135.0), followed by TP53, MUTYH, and ATM. Notably, the PALB2 c.1653T&gt;A variant was identified in five unrelated families, representing a recurrent variant compatible with a possible founder effect in this population. Overall, these findings highlight a substantial contribution of non\u2010BRCA P\/LPVs\u2014particularly PALB2\u2014in this C\u00f3rdoba\u2010based HBOC cohort. Post hoc analyses suggested sufficient statistical sensitivity to detect the observed differences; however, results should be interpreted considering the retrospective, single\u2010center design. These findings support the clinical value of incorporating non\u2010BRCA genes into multigene testing strategies in Argentina and underscore the need for larger multi\u2010center studies to confirm these observations and refine genetic counseling and surveillance strategies in Latin American populations.<\/jats:p>","DOI":"10.1002\/cam4.71846","type":"journal-article","created":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T07:13:52Z","timestamp":1776755632000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["High Prevalence of Non\u2010\n                    <scp>BRCA<\/scp>\n                    Pathogenic Variants and a Recurrent\n                    <scp>PALB2<\/scp>\n                    Variant in an Argentine Hereditary Breast and Ovarian Cancer Cohort"],"prefix":"10.1002","volume":"15","author":[{"given":"Claudia Alejandra","family":"Martin","sequence":"first","affiliation":[{"name":"Hospital Privado Universitario de C\u00f3rdoba  C\u00f3rdoba Argentina"},{"name":"Instituto Universitario de Ciencias Biom\u00e9dicas de C\u00f3rdoba (IUCBC)  C\u00f3rdoba Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catalina","family":"Bono","sequence":"additional","affiliation":[{"name":"Hospital Privado Universitario de C\u00f3rdoba  C\u00f3rdoba Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana","family":"Mandrile","sequence":"additional","affiliation":[{"name":"Hospital Privado Universitario de C\u00f3rdoba  C\u00f3rdoba Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine Susana Mercedes","family":"Kunst","sequence":"additional","affiliation":[{"name":"Hospital Privado Universitario de C\u00f3rdoba  C\u00f3rdoba Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana Elizabeth","family":"Borello","sequence":"additional","affiliation":[{"name":"Hospital Privado Universitario de C\u00f3rdoba  C\u00f3rdoba Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodolfo","family":"\u00c1vila","sequence":"additional","affiliation":[{"name":"Hospital Privado Universitario de C\u00f3rdoba  C\u00f3rdoba Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florencia Celeste","family":"Salazar","sequence":"additional","affiliation":[{"name":"Hospital Privado Universitario de C\u00f3rdoba  C\u00f3rdoba Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginia","family":"Miretti","sequence":"additional","affiliation":[{"name":"Hospital Privado Universitario de C\u00f3rdoba  C\u00f3rdoba Argentina"},{"name":"Instituto Universitario de Ciencias Biom\u00e9dicas de C\u00f3rdoba (IUCBC)  C\u00f3rdoba Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florencia","family":"Pabletich","sequence":"additional","affiliation":[{"name":"Hospital Privado Universitario de C\u00f3rdoba  C\u00f3rdoba Argentina"},{"name":"Instituto Universitario de Ciencias Biom\u00e9dicas de C\u00f3rdoba (IUCBC)  C\u00f3rdoba Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1995-8518","authenticated-orcid":false,"given":"Ver\u00f3nica","family":"Andreoli","sequence":"additional","affiliation":[{"name":"Hospital Privado Universitario de C\u00f3rdoba  C\u00f3rdoba Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2583-9289","authenticated-orcid":false,"given":"Danilo Guillermo","family":"Ceschin","sequence":"additional","affiliation":[{"name":"Hospital Privado Universitario de C\u00f3rdoba  C\u00f3rdoba Argentina"},{"name":"Instituto Universitario de Ciencias Biom\u00e9dicas de C\u00f3rdoba (IUCBC)  C\u00f3rdoba Argentina"},{"name":"Centro de Investigaci\u00f3n en Medicina Traslacional \u201cSevero R. 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