{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T01:49:17Z","timestamp":1787968157359,"version":"build-2784847793"},"reference-count":45,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T00:00:00Z","timestamp":1777161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T00:00:00Z","timestamp":1777161600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Although physical activity is associated with improved survival in lung cancer, most patients remain inactive. This study examined the impact of an oncologist's recommendation on exercise quantity, sedentary behavior, and quality of life (QoL) in patients with lung cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this single\u2010blind, 3\u2010arm randomized controlled trial, patients with lung cancer (stages I\u2013IV) were assigned to: (1) usual care, (2) the oncologist's verbal and written exercise recommendation, or (3) the recommendation plus a printed exercise guidebook. Exercise, sedentary behaviors, and QoL were assessed at baseline, 4, and 8\u2009weeks. Descriptive statistics, analysis of variance, and a generalized linear regression model were used to analyze data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, 91 patients (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200931 recommendation group,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200931 recommendation + guidebook group,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200929 controls) were randomized. At 8\u2009weeks, the recommendation group showed a significant increase in total (+270\u2009min\/week,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03) and light\u2010intensity physical activity (+236\u2009min\/week,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01) versus controls. The recommendation plus guidebook group demonstrated a near\u2010significant increase in total (+251\u2009min\/week,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.05) and moderate\u2010intensity physical activity (+145\u2009min\/week,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.05). No significant changes were observed for sedentary behaviors. Regarding QoL, at 4\u2009weeks, the recommendation plus guidebook group demonstrated an enhancement in cognitive function and the recommendation group in social function compared to controls. At 8\u2009weeks, the recommendation + guidebook group reported improved constipation compared to the controls.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A brief oncologist\u2010delivered recommendation effectively increased the total physical exercise in patients with lung cancer. Combining the oncologist's recommendation with a dedicated guidebook may be more effective in promoting moderate\u2010 and vigorous\u2010intensity exercise, although the short follow\u2010up limits conclusions regarding long\u2010term effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrial.gov\">ClinicalTrial.gov<\/jats:ext-link>\n                      identifier: NCT05497544\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71857","type":"journal-article","created":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T03:59:29Z","timestamp":1777262369000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Impact of the Oncologist's Recommendation on Exercise Levels and Quality of Life in Patients With Lung Cancer: The\n                    <scp>ORE<\/scp>\n                    Randomized Controlled Trial"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2439-4799","authenticated-orcid":false,"given":"Alice","family":"Avancini","sequence":"first","affiliation":[{"name":"Section of Oncology, Department of Engineering for Innovation Medicine (DIMI) University of Verona and University and Hospital Trust (AOUI) of Verona  Verona Italy"},{"name":"Department of Neurosciences, Biomedicine and Movement Science University of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Belluomini","sequence":"additional","affiliation":[{"name":"Section of Oncology, Department of Engineering for Innovation Medicine (DIMI) University of Verona and University and Hospital Trust (AOUI) of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Giannarelli","sequence":"additional","affiliation":[{"name":"Fondazione Policlinico Universitario A. Gemelli IRCCS\u2010Epidemiology &amp; Biostatistic  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Insolda","sequence":"additional","affiliation":[{"name":"Section of Oncology, Department of Engineering for Innovation Medicine (DIMI) University of Verona and University and Hospital Trust (AOUI) of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Borsati","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Biomedicine and Movement Science University of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Sposito","sequence":"additional","affiliation":[{"name":"Section of Oncology, Department of Engineering for Innovation Medicine (DIMI) University of Verona and University and Hospital Trust (AOUI) of Verona  Verona 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