{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T22:14:14Z","timestamp":1780352054289,"version":"3.54.1"},"reference-count":19,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T00:00:00Z","timestamp":1712707200000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012232","name":"National Key Clinical Specialty Discipline Construction Program of China","doi-asserted-by":"publisher","award":["2021QLT004"],"award-info":[{"award-number":["2021QLT004"]}],"id":[{"id":"10.13039\/501100012232","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2024,4]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>The definition of textbook outcome in biliary system cancers is a developing concept in need of expansion and investigation of its association with survival and quality of life.<\/jats:p><\/jats:sec>Methods<\/jats:title>In this original research, we developed a novel \u201call or none\u201d textbook outcome definition which addresses the rapid recovery of post\u2010surgical indexes, in addition to short\u2010term mortality, hospital re\u2010admission, prolonged stay, surgical margin and postoperative complications. Based on the fulfillment of relevant criteria, patients were divided into textbook outcome and non\u2010textbook outcome groups and their characteristics and survival data were analyzed. A customized \u201cquality of life\u201d questionnaire was developed to address short\u2010term recovery and post\u2010discharge life quality of patients. Association with quality of life improvement was then investigated.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 129 patients were included. Textbook outcome was achieved in 25.58% of patients (37.04% of gallbladder cancer patients and 17.8% of cholangiocarcinoma patients). Compared to non\u2010textbook outcome group, patients with textbook outcome had lower rate of pre\u2010operative biliary drainage (p<\/jats:italic>\u2009=\u20090.026), higher rate of normal preoperative liver function (p<\/jats:italic>\u2009<\u20090.001) and tumor markers (p<\/jats:italic>\u2009=\u20090.001), reduced perioperative bleeding (p<\/jats:italic>\u2009=\u20090.006) and blood transfusion (p<\/jats:italic>\u2009=\u20090.005), and higher rate of N0 stage cases (p<\/jats:italic>\u2009=\u20090.008). Textbook outcome was also associated with enhanced survival, significantly in older patients (<65\u2009years) (1\u2010year survival rate: 100% vs. 78.57% (p<\/jats:italic>\u2009=\u20090.108), 2\u2010year survival rate: 87.5% vs. 44% (p<\/jats:italic>\u2009=\u20090.046)). Finally, textbook outcome was significantly associated with enhanced basic daily performance (p<\/jats:italic>\u2009<\u20090.001), social life performance (p<\/jats:italic>\u2009=\u20090.033), and personal evaluation (p<\/jats:italic>\u2009<\u20090.001), and thus improved quality of life (p<\/jats:italic>\u2009<\u20090.001).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The novel definition of textbook outcome was able to address the specific nature of recovery after resection of biliary system cancers. Expanding the scope of textbook outcome and addressing the influence on survival and quality of life provides a comprehensive concept able to reflect physical, psychological and functioning enhancements in patients recovery.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.7186","type":"journal-article","created":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T13:39:43Z","timestamp":1712756383000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Novel definition of textbook outcome in biliary system cancers and its influence on patients' survival and quality of life"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9359-1676","authenticated-orcid":false,"given":"Manar Mikhail","family":"Atyah","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery China\u2013Japan Friendship Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery China\u2013Japan Friendship Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiying","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery China\u2013Japan Friendship Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aohep.2022.100737"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-010-0971-z"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29619"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000001474"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000002258"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-022-11937-y"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.27102"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000002996"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hpb.2016.11.004"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000005668"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2019.0571"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000002695"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v27.i15.1524"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.25872"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-020-08548-w"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.08.050"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2010.12.067"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-013-1083-4"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/85.5.365"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.7186","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T09:14:41Z","timestamp":1716282881000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.7186"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":19,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1002\/cam4.7186"],"URL":"https:\/\/doi.org\/10.1002\/cam4.7186","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"2023-11-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e7186"}}