{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:59:56Z","timestamp":1790949596320,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100012542","name":"Sichuan Provincial Science and Technology Support Program","doi-asserted-by":"publisher","award":["2023YFS0230"],"award-info":[{"award-number":["2023YFS0230"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012542","name":"Sichuan Provincial Science and Technology Support Program","doi-asserted-by":"publisher","award":["24NSFSC1941"],"award-info":[{"award-number":["24NSFSC1941"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Transcatheter arterial chemoembolization (TACE) is widely used for intermediate\u2010advanced hepatocellular carcinoma (HCC). The efficacy and safety of TACE combined with systemic treatments as conversion therapy for HCC remain to be explored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with intermediate\u2010advanced HCC were divided as following groups based on therapy: (1) TACE; (2) TACE combined with tyrosine kinase inhibitors (TACE+TKI); (3) TACE+TKI and immune checkpoint inhibitors (TACE+TKI+ICI); and (4) TACE combined with Bevacizumab and ICI. The progression\u2010free survival (PFS), overall survival (OS), treatment responses, and adverse events (AEs) were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the enrolled 518 patients, the overall objective response rate (ORR) was 21.0% and disease control rate (DCR) was 63.7%, while the TACE+TKI+ICI group showed highest ORR (28.9%) and DCR (72.8%). 147 (28.4%) patients experienced AEs during treatments. The TACE+TKI+ICI group significantly improved survival compared to TACE (mPFS: 20.7 vs. 10.9\u2009months,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001; mOS: 44.0 vs. 13.3\u2009months,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) or TACE+TKI (mPFS: 20.7 vs. 15.6\u2009months,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.011; mOS: 44.0 vs. 25.0\u2009months,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Of the 117 (22.6%) patients who underwent conversion liver resection, both mPFS (p\u2009=\u20090.016) and mOS (p\u2009&lt;\u20090.001) were significantly better than those without subsequent resection.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>This study demonstrated that TACE+TKI+ICI had a better ORR, manageable AEs, and superior PFS and OS compared to other TACE\u2010based conversion therapies. Undergoing subsequent liver resection significantly enhanced long\u2010term survival compared to non\u2010resection counterparts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71867","type":"journal-article","created":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T04:28:09Z","timestamp":1776745689000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Oncological Outcomes Following Different\n                    <scp>TACE<\/scp>\n                    \u2010Based Conversion Therapies for Intermediate\u2010Advanced Hepatocellular Carcinoma"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1411-3722","authenticated-orcid":false,"given":"Hongwei","family":"Xu","sequence":"first","affiliation":[{"name":"Division of Liver Surgery, Department of General Surgery West China Hospital, Sichuan University  Chengdu China"},{"name":"Department of Laboratory Medicine West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yani","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Liver Surgery, Department of General Surgery West China Hospital, Sichuan University  Chengdu China"},{"name":"Department of General Surgery West China Second Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haili","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Liver Surgery, Department of General Surgery West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haojun","family":"Wu","sequence":"additional","affiliation":[{"name":"Division of Liver Surgery, Department of General Surgery West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Liver Surgery, Department of General Surgery West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kefei","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Liver Surgery, Department of General Surgery West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3688-8795","authenticated-orcid":false,"given":"Yonggang","family":"Wei","sequence":"additional","affiliation":[{"name":"Division of Liver Surgery, Department of General Surgery West China Hospital, Sichuan University  Chengdu 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