{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T04:54:53Z","timestamp":1781585693817,"version":"3.54.5"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Ewing Sarcoma of the pelvis has poorer outcomes than other anatomical sites, with complex anatomy often precluding resection with wide margins. The role of postoperative radiotherapy (RT) in improving outcomes remains undefined. A systematic review using Medline, Embase and Cochrane databases (1972\u2013April 2024) evaluated postoperative RT's impact on local recurrence, event\u2010free survival and overall survival. Twenty\u2010nine retrospective studies (21 to 296 patients) met inclusion criteria, with 28 rated good quality. Seven of 14 studies showed improved local control with postoperative RT. Ten studies reported consistent but non\u2010significant trends favoring postoperative RT for event\u2010free survival. Nineteen studies reported mixed overall survival findings; the Euro\u2010EWING 99 trial showed significantly improved 5\u2010year survival (72% vs. 47%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.024), while others showed conflicting results. Postoperative RT should be considered for high\u2010risk features including poor response to induction chemotherapy, large tumour volume (&gt;\u2009200\u2009mL) and positive margins. Clinical trial participation should be encouraged.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial Registration:<\/jats:bold>\n                    PROSPERO registration number: CRD42021291665\n                  <\/jats:p>","DOI":"10.1002\/cam4.71870","type":"journal-article","created":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T08:02:09Z","timestamp":1777276929000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Systematic Review on the Role of Postoperative Radiotherapy in Pelvic Ewing Sarcoma"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3668-243X","authenticated-orcid":false,"given":"Angela","family":"Hong","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Health, Central Clinical School, The University of Sydney  Sydney New South Wales Australia"},{"name":"Department of Radiation Oncology Chris O'Brien Lifehouse  Camperdown New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Chris O'Brien Lifehouse  Camperdown New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Lo","sequence":"additional","affiliation":[{"name":"Mid North Coast Cancer Institute  Port Macquarie New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek A.","family":"Bhadri","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health, Central Clinical School, The University of Sydney  Sydney New South Wales Australia"},{"name":"Department of Medical Oncology Chris O'Brien Lifehouse  Camperdown New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Connor","sequence":"additional","affiliation":[{"name":"Auckland District Health Board  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Grimison","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health, Central Clinical School, The University of Sydney  Sydney New South Wales Australia"},{"name":"Department of Medical Oncology Chris O'Brien Lifehouse  Camperdown New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Smaro","family":"Lazarakis","sequence":"additional","affiliation":[{"name":"The Royal Melbourne Hospital  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4305-117X","authenticated-orcid":false,"given":"Jeremy","family":"Lewin","sequence":"additional","affiliation":[{"name":"Department of Cancer Medicine Peter MacCallum Cancer Centre  Parkville Victoria Australia"},{"name":"Victorian Adolescent &amp; Young Adult Cancer Service  Parkville Victoria Australia"},{"name":"Sir Peter MacCallum Department of Oncology The University of Melbourne  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmine","family":"Mar","sequence":"additional","affiliation":[{"name":"Australia and New Zealand Sarcoma Association  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0926-526X","authenticated-orcid":false,"given":"Wayne","family":"Nicholls","sequence":"additional","affiliation":[{"name":"Oncology Services Group, Queensland Children's Hospital  South Brisbane Queensland Australia"},{"name":"The University of Queensland Frazer Institute, Faculty of Medicine, the University of Queensland  Woolloongabba Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Orme","sequence":"additional","affiliation":[{"name":"Children's Cancer Centre, the Royal Children's' Hospital Melbourne  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne B.","family":"Phillips","sequence":"additional","affiliation":[{"name":"Department Oncology Haematology and Tissue &amp; Cellular Therapy, Perth Children's Hospital  Perth Western Australia Australia"},{"name":"The Kids Research Institute  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen R.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of New South Wales  Randwick New South Wales Australia"},{"name":"Department of Radiation Oncology Prince of Wales Hospital  Randwick New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iain","family":"Ward","sequence":"additional","affiliation":[{"name":"Christchurch Hospital  Christchurch New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Winstanley","sequence":"additional","affiliation":[{"name":"Starship Paediatric Blood &amp; Cancer Centre  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5211-1165","authenticated-orcid":false,"given":"Julie","family":"Cayrol","sequence":"additional","affiliation":[{"name":"The Royal Children's Hospital Melbourne  Parkville Victoria Australia"},{"name":"Murdoch Children's Research Institute  Parkville Victoria Australia"},{"name":"Department of Paediatrics The University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natacha","family":"Omer","sequence":"additional","affiliation":[{"name":"Oncology Services Group, Queensland Children's Hospital  South Brisbane Queensland Australia"},{"name":"The University of Queensland Frazer Institute, Faculty of Medicine, the University of Queensland  Woolloongabba Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,27]]},"reference":[{"key":"e_1_2_16_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2028910"},{"key":"e_1_2_16_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2017.08.020"},{"key":"e_1_2_16_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.26504"},{"key":"e_1_2_16_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2016.03.075"},{"key":"e_1_2_16_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19990215)85:4<869::AID-CNCR14>3.0.CO;2-8"},{"key":"e_1_2_16_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.05.9188"},{"key":"e_1_2_16_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)01790-1"},{"key":"e_1_2_16_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.41.5703"},{"key":"e_1_2_16_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2021.08.1995"},{"key":"e_1_2_16_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-017-3391-5"},{"key":"e_1_2_16_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29065"},{"key":"e_1_2_16_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(02)03797-5"},{"key":"e_1_2_16_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/CORR.0000000000000962"},{"key":"e_1_2_16_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2023.113260"},{"key":"e_1_2_16_16_1","doi-asserted-by":"publisher","DOI":"10.4103\/ortho.IJOrtho_388_17"},{"issue":"2","key":"e_1_2_16_17_1","first-page":"247","article-title":"Risk Analysis Factors for Local Recurrence in Ewing's Sarcoma: When Should Adjuvant Radiotherapy Be Administered?","volume":"100","author":"Albergo J. 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