{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T04:53:18Z","timestamp":1781585598700,"version":"3.54.5"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Microsatellite stable\/proficient mismatch repair (MSS\/pMMR) colorectal cancer liver metastases (CRCLM) have limited treatment options after failure of second\u2010line systemic therapies. Hepatic artery infusion chemotherapy (HAIC) combined with targeted therapy and immunotherapy may offer improved outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This retrospective single\u2010center study compared the efficacy and safety of HAIC (oxaliplatin, 5\u2010fluorouracil, leucovorin) combined with regorafenib and sintilimab (HAIC\u2010R\u2010S) versus regorafenib monotherapy in MSS\/pMMR CRCLM patients refractory to \u2265\u20092 lines of systemic therapy. Propensity score matching was used to balance baseline characteristics, resulting in 45 matched pairs (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200990). Survival outcomes, tumor response, and adverse events (AEs) were analyzed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The HAIC\u2010R\u2010S group showed significantly improved median progression\u2010free survival (PFS) (6.5 vs. 3.4\u2009months;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and overall survival (OS) (14.1 vs. 8.1\u2009months;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) compared to regorafenib alone. Objective response rate (ORR) (37.8% vs. 2.2%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and disease control rate (71.1% vs. 42.2%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006) were also superior. Grade \u2265\u20093 AEs were more frequent in the combination group (26.7% vs. 13.3%), primarily hematologic toxicities.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this retrospective, hypothesis\u2010generating study, HAIC (oxaliplatin, 5\u2010fluorouracil, leucovorin) combined with regorafenib and sintilimab showed improved PFS, OS, and ORRs compared with regorafenib monotherapy in refractory MSS\/pMMR CRCLM, albeit with increased hematologic toxicity. These findings require validation in prospective, multicenter randomized trials before clinical implementation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71894","type":"journal-article","created":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T16:03:27Z","timestamp":1777305807000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of Hepatic Artery Infusion Chemotherapy Combined With Regorafenib and Sintilimab Versus Regorafenib Alone in\n                    <scp>MSS<\/scp>\n                    \/\n                    <scp>pMMR<\/scp>\n                    Colorectal Cancer Liver Metastases After Second\u2010Line Treatment Failure"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3852-5569","authenticated-orcid":false,"given":"Ran","family":"You","sequence":"first","affiliation":[{"name":"Department of Interventional Radiology, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research The Affiliated Cancer Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingyu","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research The Affiliated Cancer Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixing","family":"Wang","sequence":"additional","affiliation":[{"name":"Outpatient Department Nanjing Fourth Retiree Recuperation Center of the Jiangsu Provincial Military District  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5370-342X","authenticated-orcid":false,"given":"Bin","family":"Leng","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research The Affiliated Cancer Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chendong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research The Affiliated Cancer Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeyu","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research The Affiliated Cancer Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3872-4683","authenticated-orcid":false,"given":"Ya","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology, Jiangsu Cancer Hospital, 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