{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T04:54:33Z","timestamp":1781585673767,"version":"3.54.5"},"reference-count":41,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100007452","name":"Wu Jieping Medical Foundation","doi-asserted-by":"publisher","award":["320.6750.2021\u201002\u201022"],"award-info":[{"award-number":["320.6750.2021\u201002\u201022"]}],"id":[{"id":"10.13039\/100007452","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>This study aimed to explore the clinical benefits of receiving nutritional supplementation (NS) throughout the whole course of chemotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This multicenter prospective cohort study totally included 251 cancer patients requiring nutritional support and scheduled for chemotherapy. Primary outcomes included energy intake (EI), protein intake (PI), body mass index (BMI), NRS 2002 and PG\u2010SGA scores. Short\u2010term efficacy was the secondary outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among the study participants, 168 received NS, whereas 83 opted for dietary advice (DA) alone. In the NS group, EI and PI demonstrated a gradual upward trend across the six cycles of chemotherapy, with no significant changes in the DA group. The BMI remained stable in both groups. The proportion of patients with or at risk of malnutrition showed a declining trend in the NS group but an increasing trend in the DA group. The generalized estimating equation results indicated that NS significantly improved PI (coefficient\u2009=\u20090.19, 95% CI: 0.11 to 0.27,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), NRS 2002 (coefficient\u2009=\u2009\u22120.13, 95% CI: \u22120.23 to \u22120.03,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005), and PG\u2010SGA (coefficient\u2009=\u2009\u22120.18, 95% CI: \u22120.28 to \u22120.08,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The improvements in PI, NRS 2002, and PG\u2010SGA scores occurred from cycle 1, cycle 3, and cycle 2, respectively. Multivariate logistic analysis confirmed NS as a favorable factor associated with higher disease control rate (OR\u2009=\u20094.65, 95% CI: [1.88, 12.01],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The incorporation of NS yielded several clinical benefits beyond adequate EI and stable weight. It contributes to higher protein intake and good nutritional status in patients with cancer throughout the whole course of chemotherapy, ultimately improving treatment efficacy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>Patient\u2010Reported Outcome Management Including Surveillance and Intervention in Nutritional Group (PROMISING) Study (registration number: ChiCTR2100047535)<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71896","type":"journal-article","created":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T05:21:51Z","timestamp":1777699311000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Clinical Benefits of Nutritional Supplementation Across the Chemotherapy Journey in Cancer Patients: A Multicenter Prospective Cohort Study"],"prefix":"10.1002","volume":"15","author":[{"given":"Jia\u2010Xin","family":"Huang","sequence":"first","affiliation":[{"name":"Comprehensive Oncology Department National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si\u2010Wei","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Environmental Health and Engineering Johns Hopkins Bloomberg School of Public Health  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui\u2010Min","family":"Qu","sequence":"additional","affiliation":[{"name":"Department of Medicine Gesi (Hebei) Medical Research Institute  Langfang Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi\u2010Gang","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Medicine Gesi (Hebei) Medical Research Institute  Langfang Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin\u2010Yi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medicine Gesi (Hebei) Medical Research Institute  Langfang Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Oncology Ordos Central Hospital  Ordos City Inner Mongolia Autonomous Region China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan\u2010Fu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Oncology Ordos Central Hospital  Ordos City Inner Mongolia Autonomous Region China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Oncology Ordos Central Hospital  Ordos City Inner Mongolia Autonomous Region China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Oncology Ordos Central Hospital  Ordos City Inner Mongolia Autonomous Region China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[{"name":"Mianyang Cancer Hospital  Mianyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun\u2010Chun","family":"Yao","sequence":"additional","affiliation":[{"name":"Mianyang Cancer Hospital  Mianyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Hui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oncology Chifeng Municipal Hospital  Chifeng China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian","family":"Shen","sequence":"additional","affiliation":[{"name":"Zhejiang Key Laboratory of Intelligent Cancer Biomarker Discovery and Translation, First Affiliated Hospital Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Dong","family":"Chen","sequence":"additional","affiliation":[{"name":"Zhejiang Key Laboratory of Intelligent Cancer Biomarker Discovery and Translation, First Affiliated Hospital Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Li","sequence":"additional","affiliation":[{"name":"Comprehensive Oncology Department National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Comprehensive Oncology Department National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le","family":"Tian","sequence":"additional","affiliation":[{"name":"Comprehensive Oncology Department National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Yang","sequence":"additional","affiliation":[{"name":"Comprehensive Oncology Department National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Tang","sequence":"additional","affiliation":[{"name":"Comprehensive Oncology Department National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen\u2010Xin","family":"Song","sequence":"additional","affiliation":[{"name":"Comprehensive Oncology Department National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bao\u2010Hua","family":"Zou","sequence":"additional","affiliation":[{"name":"Comprehensive Oncology Department National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng\u2010Ling","family":"Qin","sequence":"additional","affiliation":[{"name":"Comprehensive Oncology Department National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Qin","sequence":"additional","affiliation":[{"name":"Comprehensive Oncology Department National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Hua","family":"Cong","sequence":"additional","affiliation":[{"name":"Comprehensive Oncology Department National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,1]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-01195-4"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdw271"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.55.2281"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2016.12.003"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2023.107074"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41430-018-0245-4"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx271"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12955-021-01735-7"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15041044"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2018.05.016"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2021.02.005"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000529617"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2016.07.015"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607109341804"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdy114"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11051145"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2022.2074474"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21388"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0261\u20105614(02)00214\u20105"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0000000000000389"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2008.10.026"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.01254"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2013.06.012"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-017-0812-x"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2016.01.002"},{"key":"e_1_2_13_27_1","article-title":"Dietary Advice With or Without Oral Nutritional Supplements for Disease\u2010Related Malnutrition in Adults","volume":"12","author":"Baldwin C.","year":"2021","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2021.10.041"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21719"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2019.110558"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11051145"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13020306"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-nutr-120919-094440"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdn311"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16162809"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1987.5.1.113"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2014.03.006"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2021.11.032"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114509991310"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2025.02.022"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/83.6.1345"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15194232"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.71896","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cam4.71896","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.71896","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T04:15:47Z","timestamp":1781583347000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.71896"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":41,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1002\/cam4.71896"],"URL":"https:\/\/doi.org\/10.1002\/cam4.71896","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"2024-12-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71896"}}