{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T05:44:02Z","timestamp":1785822242155,"version":"3.56.0"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100006364","name":"Institut National Du Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006364","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Metastatic Ewing sarcoma (MES) has a poor prognosis. This multicenter observational study provides real\u2010world data on treatment patterns of patients with MES in France. Treatment characteristics, outcomes such as time to next treatment (TTNT) and overall survival (OS), and prognostic factors of patients aged \u2265\u200912\u2009years treated for a MES in 11 French reference network centers were retrieved from our national database. From 2008 to 2018, 156 patients with MES were included: 82 were metastatic at diagnosis (upfront metastatic cohort), 74 had developed secondary metastases after treatment of a localized disease (metastatic relapse cohort). 94% of patients received systemic treatment, with a median of three lines (1\u201311), 61% had at least one loco\u2010regional procedure and 42% of patients participated in a clinical trial in the metastatic setting. Median OS from metastatic diagnosis was 20.3\u2009months [95% CI 14.0; 27.7] in the metastatic relapse cohort and 31.4\u2009months [95% CI 26.5; 42.5] in the upfront metastatic cohort (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.02). Median TTNT in first metastatic line was 16.8\u2009months [95% CI 12.9; 21.3] in the upfront metastatic cohort and 7.4\u2009months [95% CI 5.0; 11.1] in the metastatic relapse cohort, 5.8\u2009months [95% CI 3.6; 7.3] in 2nd line and 3.8\u2009months [95% CI 2.8; 5.7] in 3rd line, without significant difference between cohorts and treatment regimens. Patients with upfront MES have a longer OS than patients with relapsing disease, mainly due to first metastatic line dose\u2010dense polychemotherapy and loco\u2010regional procedures in selected patients. Main regimens used at relapse are associated with the same range of benefit and survival, while TKIs such as regorafenib or cabozantinib have modest activity. Inclusion in clinical trials should be prioritized.\n                  <\/jats:p>","DOI":"10.1002\/cam4.71909","type":"journal-article","created":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T03:45:48Z","timestamp":1780544748000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Metastatic Ewing Sarcoma, Patterns of Care and Outcomes of Patients in a Real\u2010Life National Setting Over a Decade"],"prefix":"10.1002","volume":"15","author":[{"given":"Coline","family":"Ducrot","sequence":"first","affiliation":[{"name":"Centre L\u00e9on B\u00e9rard  Lyon France"},{"name":"Centre de Recherche en Canc\u00e9rologie de Lyon (CRCL), \u00e9quipe Mort Cellulaire et Cancer de L'enfant  Lyon France"},{"name":"H\u00f4pital Femme M\u00e8re Enfant Hospices Civils de Lyon  Bron France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek","family":"Dinart","sequence":"additional","affiliation":[{"name":"Institut Bergoni\u00e9  Bordeaux France"},{"name":"Inserm CIC1401, Clinical and Epidemiological Research Unit Institut Bergoni\u00e9  Bordeaux France"},{"name":"University of Bordeaux BPH, Epicene Team, UMR 1219  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maeva","family":"Bonneau","sequence":"additional","affiliation":[{"name":"Institut Universitaire du Cancer de Toulouse  Oncopole France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"Piffoux","sequence":"additional","affiliation":[{"name":"Centre L\u00e9on B\u00e9rard  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9693-9850","authenticated-orcid":false,"given":"Marie Sophie","family":"Minot","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire Cochin APHP  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliane","family":"Mignot\u2010Posson","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire de Nantes  Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Grinda","sequence":"additional","affiliation":[{"name":"Institut Gustave Roussy  Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4482-0065","authenticated-orcid":false,"given":"Jordane","family":"Chaix","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire Pellegrin  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Winter","sequence":"additional","affiliation":[{"name":"Institut Curie  Paris 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Universitaire Cochin APHP  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascaline","family":"Boudou\u2010Rouquette","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire Cochin APHP  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"Bompas","sequence":"additional","affiliation":[{"name":"Institut de Canc\u00e9rologie de L'ouest  Saint\u2010Herblain France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thibaud","family":"Valentin","sequence":"additional","affiliation":[{"name":"Institut Universitaire du Cancer de Toulouse  Oncopole France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nad\u00e8ge","family":"Corradini","sequence":"additional","affiliation":[{"name":"Centre L\u00e9on B\u00e9rard  Lyon 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C.Nad\u00e8ge Corradini N. J.Sylvain Dureau N. G.Gaelle Pierron et\u00a0al. \u201cInterest of a Sequential Multimodal Approach for the Treatment of Newly Diagnosed Patients With Multimetastatic Ewing Sarcoma: Results of the French Prospective Combinair3 Phase II Trial \u201dConnective Tissue Oncology Society Annual Meeting 2024 San Diego 2024."},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(19)30825\u20103"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416\u2010023\u201002413\u20109"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/CAM4.5044"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2017.59"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.PRRO.2024.10.004"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2016.34.15_suppl.11521"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916\u2010017\u20100831\u20107"}],"updated-by":[{"DOI":"10.1002\/cam4.72136","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000}}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.71909","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cam4.71909","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.71909","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T10:06:19Z","timestamp":1784196379000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.71909"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":22,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/cam4.71909"],"URL":"https:\/\/doi.org\/10.1002\/cam4.71909","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"2025-08-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71909"}}