{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:35:29Z","timestamp":1786977329670,"version":"build-2736575974"},"reference-count":59,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T00:00:00Z","timestamp":1714003200000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Patients with nasopharyngeal carcinoma (NPC) undergoing radiotherapy experience significant fatigue, which is frequently underestimated due to the lack of objective indicators for its evaluation. This study aimed to explore the longitudinal association between fatigue and nutrition status 1\u2009week in advance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>From January 2021 to June 2022, a total of 105 NPC patients who received intensity\u2010modulated radiation therapy were enrolled in the observational longitudinal study. The significant outcomes, including the Piper Fatigue Scale\u201012 (PFS\u201012), the Scored Patient\u2010Generated Subjective Global Assessment (PG\u2010SGA), four body composition indices, and the Hospital Anxiety and Depression Scale (HADS), were assessed weekly from pre\u2010treatment until the completion of radiotherapy (T0\u2013T7) to explore their relationship.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The trajectories of PFS\u201012 and all dimensions for 105 participants reached a peak during the fifth week. Sensory fatigue consistently received the highest scores (T0\u2009=\u20091.60\u2009\u00b1\u20092.20, T5\u2009=\u20096.15\u2009\u00b1\u20091.57), whereas behavior fatigue exhibited the fastest increase over time (T0\u2009=\u20091.11\u2009\u00b1\u20091.86, T5\u2009=\u20095.47\u2009\u00b1\u20091.70). Higher PG\u2010SGA scores were found to be weakly explainable for aggravating fatigue (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u20090.02\u2009~\u20090.04). Unlike generalized additive mixed models, marginal structural models (MSM) produced larger effect values (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u20090.12\u2009~\u20090.21). Additionally, body composition indices showed weakly negative relationships with fatigue in MSMs one week in advance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The PG\u2010SGA may be a more accurate predictor of future\u2010week fatigue than individual body composition indicators, particularly when HADS is controlled for as a time\u2010dependent confounder.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.7191","type":"journal-article","created":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T03:29:11Z","timestamp":1714015751000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Could nutrition status predict fatigue one week before in patients with nasopharynx cancer undergoing radiotherapy?"],"prefix":"10.1002","volume":"13","author":[{"given":"Jihong","family":"Song","sequence":"first","affiliation":[{"name":"School of Nursing Health Science Center, Xi'an Jiaotong University  Xi'an China"},{"name":"School of Nursing Fujian Medical University  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinru","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Nursing Fujian Medical University  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5258-1583","authenticated-orcid":false,"given":"Jieling","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Nursing Fujian Medical University  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zilan","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Nursing Fujian Medical University  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Litao","family":"Zhuo","sequence":"additional","affiliation":[{"name":"School of Nursing Fujian Medical University  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinsheng","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy Cancer Center, the First Affiliated Hospital of Fujian Medical University  Fuzhou China"},{"name":"Department of Radiotherapy National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University  Fuzhou China"},{"name":"Key Laboratory of Radiation Biology of Fujian Higher Education Institutions, The First Affiliated Hospital, Fujian Medical University  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy Cancer Center, the First Affiliated Hospital of Fujian Medical University  Fuzhou China"},{"name":"Department of Radiotherapy National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University  Fuzhou China"},{"name":"Key Laboratory of Radiation Biology of Fujian Higher Education Institutions, The First Affiliated Hospital, Fujian Medical University  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenlong","family":"Lyu","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy Cancer Center, the First Affiliated Hospital of Fujian Medical University  Fuzhou China"},{"name":"Department of Radiotherapy National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University  Fuzhou China"},{"name":"Key Laboratory of Radiation Biology of Fujian Higher Education Institutions, The First Affiliated Hospital, Fujian Medical University  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinru","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy Cancer Center, the First Affiliated Hospital of Fujian Medical University  Fuzhou China"},{"name":"Department of Radiotherapy National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University  Fuzhou China"},{"name":"Key Laboratory of Radiation Biology of Fujian Higher Education Institutions, The First Affiliated Hospital, Fujian Medical University  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Fang","sequence":"additional","affiliation":[{"name":"Nursing Department The First Affiliated Hospital of Fujian Medical University  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiying","family":"Zhan","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Statistics Fujian Provincial Key Laboratory of Environment Factors and Cancer, School of Public Health, Fujian Medical University  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hairong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Fujian Center for Disease Control and Prevention  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomei","family":"Li","sequence":"additional","affiliation":[{"name":"School of Nursing Health Science Center, Xi'an Jiaotong University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,25]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2016.01.040"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.579292"},{"issue":"23","key":"e_1_2_12_4_1","first-page":"6","article-title":"Changes of symptom clusters among nasopharyngeal carcinoma patients undergoing concurrent chemoradiotherapy: a longitudinal study","volume":"26","author":"Zhang N","year":"2019","journal-title":"J Nursing (China)"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-021-06054-7"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2021.567085"},{"key":"e_1_2_12_7_1","unstructured":"AnnM BergerP et\u00a0al.NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines\u00ae). [J]. Cancer\u2010Rrelated Fatigue (NCCN Guidelines Version 1.2021)[EB\/OL].2021."},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm-21-3412"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.45.2722"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euf.2016.11.009"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/nqab285"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2020.104771"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1188\/21.ONF.558-576"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-017-1539-z"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-020-05624-3"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11764-020-00953-0"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-019-04953-4"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.594687"},{"key":"e_1_2_12_19_1","first-page":"1858","article-title":"A longitudinal study of cancer\u2010related fatigue and its influencing factors in patients with nasopharyngeal carcinoma undergoing concurrent chemoradiotherapy","volume":"18","author":"Shuai Z","year":"2020","journal-title":"Oncol Progress"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2018.12.023"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2021.02.005"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-012-2212-4"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/pzac120"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0000000000000389"},{"issue":"3","key":"e_1_2_12_25_1","first-page":"121","article-title":"Nutritional assessment tools for the identification of malnutrition and nutritional risk associated with cancer treatment","volume":"70","author":"Castillo\u2010Martinez L","year":"2018","journal-title":"Rev Invest Clin"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2020.09.033"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3999(01)00296-3"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejon.2016.09.004"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/jts.20271"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejon.2017.01.004"},{"issue":"2","key":"e_1_2_12_31_1","first-page":"198","article-title":"Reliability and validity of hospital anxiety and depression scale","volume":"11","author":"Zhenxiao S","year":"2017","journal-title":"Chin J Clinicians"},{"key":"e_1_2_12_32_1","first-page":"98","article-title":"Theoretical basis and research application of the social support rating scale","volume":"2","author":"Shuiyuan X","year":"1994","journal-title":"Psychol Med"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1249\/01.MSS.0000078924.61453.FB"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1368980010002806"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17197161"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2010.03353.x"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.8792"},{"issue":"2","key":"e_1_2_12_38_1","first-page":"200","article-title":"Correlation of nutritional status and quality of life in patients with locally advanced nasopharyngeal carcinoma after concurrent radiotherapy and chemotherapy","volume":"4","author":"Xia W","year":"2012","journal-title":"Chinese J Cancer Prev Treat"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2013.06.042"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.14932"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2016.1115099"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1188\/02.ONF.1334-1340"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-66513-9"},{"issue":"9","key":"e_1_2_12_44_1","first-page":"2591","article-title":"Effects of exergaming in cancer related fatigue in the quality of life and electromyography of the middle deltoid of people with cancer in treatment: a controlled trial","volume":"19","author":"Oliveira PF","year":"2018","journal-title":"Asian Pac J Cancer Prev"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1177\/1534735418807969"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.33993"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114522003051"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-022-01732-2"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201410-1830PP"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1080\/13803395.2019.1614535"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.34531"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.3389\/fspor.2021.687365"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-019-4660-4"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1037\/hea0000652"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.32927"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocn.14245"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11051193"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12072110"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10865-019-00084-7"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1093\/biostatistics\/kxac027"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.7191","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T02:36:34Z","timestamp":1715826994000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.7191"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":59,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1002\/cam4.7191"],"URL":"https:\/\/doi.org\/10.1002\/cam4.7191","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"2023-11-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e7191"}}