{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T04:54:14Z","timestamp":1781585654654,"version":"3.54.5"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T00:00:00Z","timestamp":1778371200000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100010256","name":"Guangzhou Municipal Science and Technology Project","doi-asserted-by":"publisher","award":["2025A04J5219"],"award-info":[{"award-number":["2025A04J5219"]}],"id":[{"id":"10.13039\/501100010256","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82200221"],"award-info":[{"award-number":["82200221"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270209"],"award-info":[{"award-number":["82270209"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82470197"],"award-info":[{"award-number":["82470197"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Minimal residual disease (MRD) testing is essential for evaluating treatment response among multiple myeloma (MM) patients. Many patients experience MRD progression (MRD\u2010P) before they meet the criteria for clinical or biochemical progression (PD), thus raising questions about the timing of treatment. In this retrospective study, the effect of early intervention (EI) on prognosis was investigated among 42 newly diagnosed MM patients who developed MRD\u2010P after initial treatment with autologous stem cell transplantation. In the EI group (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20099), treatment was modified at the onset of MRD\u2010P; in the PD group (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200933), treatment was delayed until disease progression occurred. At a median follow\u2010up of 25\u2009months, compared with the PD group, the EI group demonstrated a longer time to progression (median 34.8\u2009months vs. 6.6\u2009months,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.029), superior overall survival (median not reached vs. 41.0\u2009months,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.034), and significantly higher MRD re\u2010negativity rates (median 12.6\u2009months vs. 75.9\u2009months,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Multivariate analysis revealed that early intervention was significantly associated with improved MRD re\u2010negativity (HR\u2009=\u20090.07;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.001). This hypothesis\u2010generating retrospective study demonstrated that early intervention at MRD\u2010P onset was associated with improved survival outcomes and higher rates of MRD re\u2010negativity in this cohort. Despite significant limitations, such as the small sample size, nonrandomized design, and unmeasured confounders, these findings provide preliminary data to inform the design of future prospective randomized trials.\n                  <\/jats:p>","DOI":"10.1002\/cam4.71911","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T03:16:08Z","timestamp":1778469368000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Outcomes Among\n                    <scp>MM<\/scp>\n                    Patients Receiving Early Intervention for\n                    <scp>MRD<\/scp>\n                    Progression Following Autologous Stem Cell Transplantation"],"prefix":"10.1002","volume":"15","author":[{"given":"Xiaozhe","family":"Li","sequence":"first","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meilan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifen","family":"Kuang","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6462-3547","authenticated-orcid":false,"given":"Junru","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beihui","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0909-4731","authenticated-orcid":false,"given":"Juan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,10]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00135-5"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2022007082"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)30206-6"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2023020284"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408363.2023.2209652"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021011101"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2021005822"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-024-01102-x"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2023022083"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2023023293"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2023022080"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-025-01219-7"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-024-01537-2"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.00622"},{"key":"e_1_2_14_16_1","first-page":"2049","article-title":"Role of Minimal Residual Disease Assessment in Multiple Myeloma","volume":"109","author":"Szalat R.","year":"2024","journal-title":"Haematologica"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2015.356"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2020-139230"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.776920"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2018.07.040"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(23)00240-5"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(23)00236-3"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-024-12077-0"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-024-02366-9"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.2174\/1574887117666220516145628"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2025.03.002"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.71911","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cam4.71911","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.71911","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T04:20:29Z","timestamp":1781583629000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.71911"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":25,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1002\/cam4.71911"],"URL":"https:\/\/doi.org\/10.1002\/cam4.71911","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"2025-08-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71911"}}