{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T11:04:47Z","timestamp":1784199887021,"version":"3.55.0"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T00:00:00Z","timestamp":1780790400000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Insomnia is a common clinical symptom that significantly impairs quality of life (QOL) and it frequently occurs in cancer patients. However, the risk of insomnia in Japanese cancer patients compared with cancer\u2010free patients has not yet been studied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study evaluated the association between cancer diagnosis and the risk of insomnia disorder in the Japanese health insurance claims database.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A population\u2010based matched cohort study was performed comparing cancer patients with cancer\u2010free patients. The primary outcome was the time to onset of insomnia disorder in cancer and cancer\u2010free patients. Multivariate analyses were performed to determine hazard ratio (HR) for all patients and for each cancer type.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 36,230 cancer patients and 362,300 cancer\u2010free patients were enrolled in this study. The median age was 53\u2009years. Among cancer patients, the time to onset of insomnia disorder was significantly shorter than that of cancer\u2010free patients (stratified log\u2010rank testing;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). In the multivariate analysis, the HR of cancer status (HR 3.39; 95% CI 3.28\u20133.49) was largest. In the subgroup analysis, the insomnia disorder risk was highest in patients with esophageal cancer, multiple cancers, gallbladder\/biliary tract cancer, and bone and articular cartilage cancer.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study shows that Japanese cancer patients have a higher risk of developing insomnia disorder compared with cancer\u2010free patients. The risk was especially high in cancer types which have a poor prognosis or impair the QOL of patients. These findings highlight the importance of assessing insomnia disorder frequently in cancer patients and providing interventions when it is needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71913","type":"journal-article","created":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T03:11:52Z","timestamp":1780888312000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Risk of Insomnia Disorder in Japanese Cancer Patients: A Matched Cohort Study Using Employer\u2010Based Health Insurance Claims Data"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-4232-1168","authenticated-orcid":false,"given":"Risa","family":"Murakami","sequence":"first","affiliation":[{"name":"Department of Clinical Biostatistics, Graduate School of Medical and Dental Sciences Institution of Science Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9507-9887","authenticated-orcid":false,"given":"Hiroyuki","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Clinical Biostatistics, Graduate School of Medical and Dental Sciences Institution of Science Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2580-7460","authenticated-orcid":false,"given":"Akihiro","family":"Hirakawa","sequence":"additional","affiliation":[{"name":"Department of Clinical Biostatistics, Graduate School of Medical and Dental Sciences Institution of Science Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,7]]},"reference":[{"key":"e_1_2_11_2_1","volume-title":"StatPearls [Internet]","author":"Karna 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