{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T04:54:09Z","timestamp":1781585649593,"version":"3.54.5"},"reference-count":42,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To explore a safe and effective treatment modality for unresectable huge (\u2265\u200910\u2009cm) hepatocellular carcinoma with portal vein thrombosis. And to provide more data on the synergistic antitumor effects of radiotherapy combined with immune checkpoint inhibitors and antiangiogenic therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>This study compared the clinical outcomes in 63 patients with unresectable huge hepatocellular carcinoma and portal vein thrombosis who were treated with either \u03b3\u2010ray body radiotherapy or linear accelerator radiotherapy (the RT\u03b3 and RTa groups, respectively), both combined with immune checkpoint inhibitors and antiangiogenic therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The median progress\u2010free survival (PFS) and median overall survival (OS) in the RT\u03b3 group were 12.1 and 14.3\u2009months, respectively. And those in the RTa group were 6.6 and 8.1\u2009months, respectively. The 1\u2010, 2\u2010, and 3\u2010year PFS were 43.2%, 24.3%, 10.8% in the RT\u03b3 group and 11.5%, 3.8%, 0% in the RTa group, respectively. The OS at the same intervals were 56.7%, 40.5%, and 18.9% in the RT\u03b3 group, and those were 23.1%, 7.7%, and 0% in the RTa group, respectively. The percentage of normal liver volume (NLV) in whole liver volume (WLV) &gt;\u200960% and negative viral infection are significant independent factors for superior PFS and OS. Severe radiation\u2010induced liver disease was observed in 23.1% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20096) of patients in the RTa group, compared to none in the RT\u03b3 group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>RT\u03b3 combined with immune checkpoint inhibitors and antiangiogenic therapy is an effective and safe treatment modality for unresectable huge hepatocellular carcinoma with portal vein thrombosis. An NLV\/WLV ratio &gt;\u200960% and negative viral infection independently predicted better PFS and OS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71926","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T04:49:36Z","timestamp":1778647776000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Differences in Clinical Outcomes for Unresectable Huge (\u2265\u200910\u2009cm) Hepatocellular Carcinoma With Portal Vein Thrombosis Treated by Two Different Radiotherapy Techniques"],"prefix":"10.1002","volume":"15","author":[{"given":"ZengLiang","family":"Huang","sequence":"first","affiliation":[{"name":"Interventional Ward of the Radiology Department 900th Hospital of PLA  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ZhongHua","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Tumor Radiotherapy 900th 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