{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T04:54:09Z","timestamp":1781585649620,"version":"3.54.5"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The impact of age on perioperative morbidity and long\u2010term oncologic outcomes in colorectal cancer remains controversial. Although aging is linked to greater comorbidity and functional decline, advances in perioperative care have challenged the idea that older patients have worse outcomes. This study evaluated surgical and oncologic results in patients aged \u2265\u200975\u2009years compared with younger individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective cohort study including patients who underwent colorectal resection with primary anastomosis between 2015 and 2022. Patients were grouped by age (&lt;\u200975 vs. \u2265\u200975\u2009years) and matched 1:1 using propensity scores based on preoperative clinical and tumor\u2010related variables. Major complications (Clavien\u2013Dindo grade \u2265\u2009III) were analyzed using logistic regression, and OS and RFS were assessed using Kaplan\u2013Meier curves and Cox proportional hazards models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 651 eligible patients, 272 were included in the matched cohort. No statistically significant differences were found between age groups in hospital stay (4.5 vs. 4.0\u2009days;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.270), reintervention (13.2% vs. 8.8%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.333), major complications (14.0% vs. 8.8%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.252), or 30\u2010day perioperative mortality (3.7% vs. 0.7%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.216), although perioperative mortality was numerically higher among patients aged \u2265\u200975\u2009years. Age\u2009\u2265\u200975\u2009years was not significantly associated with major complications in multivariable analysis (OR 1.73; 95% CI 0.79\u20133.94). Five\u2010year OS and RFS also did not differ significantly between groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Older age was not associated with statistically significant differences in major complications or long\u2010term oncologic outcomes in this matched cohort. However, clinically meaningful differences, particularly in short\u2010term perioperative risk, cannot be excluded. Chronological age alone should not preclude curative\u2010intent surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71927","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T04:51:38Z","timestamp":1778647898000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Age on Surgical and Oncologic Outcomes After Colorectal Cancer Resection in Selected Patients Undergoing Primary Anastomosis: A Retrospective Propensity\u2010Matched Cohort Study"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1929-2299","authenticated-orcid":false,"given":"Camilo","family":"Ram\u00edrez\u2010Giraldo","sequence":"first","affiliation":[{"name":"Department of Surgery Hospital Universitario Mayor \u2013 M\u00e9deri  Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8509-6966","authenticated-orcid":false,"given":"Pablo","family":"Gonz\u00e1lez\u2010Sierra","sequence":"additional","affiliation":[{"name":"Grupo de Investigaci\u00f3n Cl\u00ednica, Escuela de Medicina y Ciencias de la Salud Universidad del Rosario  Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7659-2759","authenticated-orcid":false,"given":"Natalia","family":"Amado\u2010Pe\u00f1a","sequence":"additional","affiliation":[{"name":"Grupo de Investigaci\u00f3n Cl\u00ednica, Escuela de Medicina y Ciencias de la Salud Universidad del Rosario  Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6949-1093","authenticated-orcid":false,"given":"Marian","family":"Ochoa\u2010Patarroyo","sequence":"additional","affiliation":[{"name":"Grupo de Investigaci\u00f3n Cl\u00ednica, Escuela de Medicina y Ciencias de la Salud Universidad del Rosario  Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9286-2668","authenticated-orcid":false,"given":"Nicol\u00e1s","family":"Navarro\u2010Pulido","sequence":"additional","affiliation":[{"name":"Grupo de Investigaci\u00f3n Cl\u00ednica, Escuela de Medicina y Ciencias de la Salud Universidad del Rosario  Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3890-3726","authenticated-orcid":false,"given":"Alejandro Gonz\u00e1lez","family":"Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Grupo de Investigaci\u00f3n Cl\u00ednica, Escuela de Medicina y Ciencias de la Salud Universidad del Rosario  Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1950-194X","authenticated-orcid":false,"given":"Juan Carlos","family":"Vallejo\u2010Soto","sequence":"additional","affiliation":[{"name":"Grupo de Investigaci\u00f3n Cl\u00ednica, Escuela de Medicina y Ciencias de la Salud Universidad del Rosario  Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Figueroa\u2010Avenda\u00f1o","sequence":"additional","affiliation":[{"name":"Department of Surgery Hospital Universitario Mayor \u2013 M\u00e9deri  Bogot\u00e1 Colombia"},{"name":"Grupo de Investigaci\u00f3n Cl\u00ednica, Escuela de Medicina y Ciencias de la Salud Universidad del Rosario  Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1569-969X","authenticated-orcid":false,"given":"Andr\u00e9s","family":"Isaza\u2010Restrepo","sequence":"additional","affiliation":[{"name":"Department of Surgery Hospital Universitario Mayor \u2013 M\u00e9deri  Bogot\u00e1 Colombia"},{"name":"Grupo de Investigaci\u00f3n Cl\u00ednica, Escuela de Medicina y Ciencias de la Salud Universidad del Rosario  Bogot\u00e1 Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003134821995060"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12957\u2010020\u201001895\u20108"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.asjsur.2021.04.046"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(18)30646\u20106"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2018.02.003"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(15)00223\u20105"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2019.103208"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/JS9.0000000000001268"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/1475\u20106773.12182"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm\u201020\u20103998"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jep.12072"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1214\/09\u2010STS313"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2016.07.17"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2016.08.61"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina60121951"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000000578"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2016.09.006"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12094\u2010024\u201003758\u20100"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434\u2010016\u20105445\u20103"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2021.08.013"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/00015458.2018.1515395"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/ans.13666"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2024.09.027"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e318216f56e"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/23779608221106444"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12029\u2010025\u201001290\u20100"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.4103\/jcrt.jcrt_1478_21"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2024.1326292"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.21037\/jgo\u201021\u2010627"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/ans.17972"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1080\/13645706.2024.2360094"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.71927","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cam4.71927","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.71927","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T04:19:10Z","timestamp":1781583550000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.71927"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1002\/cam4.71927"],"URL":"https:\/\/doi.org\/10.1002\/cam4.71927","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"2025-11-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71927"}}