{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T04:54:02Z","timestamp":1781585642357,"version":"3.54.5"},"reference-count":60,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Obesity is critical for cancer prognosis, but the impact of visceral obesity indices on survival in cancer survivors remains unclear. This study explored associations between six visceral obesity indices, BMI, and overall survival using two large population\u2010based cohorts of cancer survivors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective cohort study was conducted using data from the 2001 to 2018 National Health and Nutrition Examination Survey (NHANES) and China Health and Retirement Longitudinal Study (CHARLS). Visceral obesity was assessed by a body shape index (ABSI), conicity index (ConI), visceral adiposity index (VAI), Chinese visceral adiposity index (CVAI), metabolic score for visceral fat (METS\u2010VF), and lipid accumulation product (LAP). Kaplan\u2013Meier curves, multivariable Cox regression, restricted cubic splines (RCS), mediation analysis, subgroup, and sensitivity analyses were employed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study included 1783 NHANES survivors (weighted population: 8,556,033; weighted median follow\u2010up 85\u2009months) and 162 CHARLS patients (weighted population: 5,631,233; weighted median follow\u2010up 37\u2009months). Only ABSI was significantly associated with increased all\u2010cause mortality risk in both cohorts (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). In NHANES, individuals in the highest ABSI level had 80% increased mortality risk compared to the lowest level (adjusted HR 1.80;\n                      <jats:italic>p<\/jats:italic>\n                      for trend\u2009=\u20090.004), consistent with CHARLS. RCS showed a linear ABSI\u2010mortality relationship. Mediation analyses indicated that neutrophil mediated 16.77% proportion of the ABSI\u2010mortality association in NHANES. Subgroup analyses and sensitivity analyses further confirmed these findings.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Compared to other indices, ABSI may be a valuable, potentially independent predictor of survival in cancer survivors, highlighting its value for clinical assessment to identify high\u2010risk individuals and guide targeted interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71938","type":"journal-article","created":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T04:21:43Z","timestamp":1778905303000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of Visceral Obesity Indices With Survival Among Cancer Survivors: Evidence From Two Nationally Population\u2010Based Cohort 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