{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T09:42:36Z","timestamp":1785577356325,"version":"3.56.0"},"reference-count":36,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T00:00:00Z","timestamp":1717718400000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Myc rearrangement (Myc\u2010R) is a controversial factor linked to adverse outcomes in newly diagnosed multiple myeloma (NDMM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>This study aimed to evaluate the impact of Myc\u2010R on the prognosis of NDMM patients and its role in risk stratification compared with traditional high\u2010risk cytogenetic abnormalities (HRCAs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials &amp; Methods<\/jats:title><jats:p>A total of 417 NDMM patients enrolled from May 2009 to September 2022 were included. Fluorescence in\u00a0situ hybridization (FISH) was used to detect Myc\u2010R and other Myc abnormalities (Myc\u2010OA). Median progression\u2010free survival (PFS) and overall survival (OS) were analyzed using Kaplan\u2013Meier methods and log\u2010rank tests. Multivariate Cox regression analysis was used to identify independent risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Myc\u2010R was identified in 13.7% of patients, while 14.6% had Myc\u2010OA. Patients with Myc\u2010R had significantly shorter median PFS (15.9\u2009months) and OS (25.1\u2009months) compared with those with Myc\u2010OA (24.5\u2009months PFS; 29.8\u2009months OS) and Myc\u2010negative (Myc\u2010N) status (29.8\u2009months PFS, 29.8\u2009months OS). Myc\u2010R was independently associated with worse PFS and OS compared to Myc\u2010OA. Patients with Myc\u2010R alone had inferior median PFS (15.9\u2009months vs. 28.1\u2009months, <jats:italic>p<\/jats:italic>\u2009=\u20090.032) and OS (25.1\u2009months vs. 61.2\u2009months, <jats:italic>p<\/jats:italic>\u2009=\u20090.04) compared to those with traditional single HRCA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The study suggests that traditional single HRCA may not significantly impact survival in NDMM patients. However, incorporating Myc rearrangement or traditional double\/triple\u2010hit HRCAs into the risk stratification model improves its predictive value, highlighting the importance of Myc rearrangement in risk assessment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Myc rearrangement is an independent adverse prognostic factor in NDMM. The incorporation of Myc rearrangement or multiple HRCAs into risk stratification models improves their prognostic value, providing a novel perspective on high\u2010risk factors in NDMM.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.7194","type":"journal-article","created":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T07:45:20Z","timestamp":1717746320000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Myc rearrangement redefines the stratification of high\u2010risk multiple myeloma"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3140-5521","authenticated-orcid":false,"given":"Xianghong","family":"Jin","sequence":"first","affiliation":[{"name":"Department of Hematology, Peking Union Medical College Hospital Chinese Academy of Medical Sciences  Beijing China"},{"name":"Department of Rare Diseases Peking Union Medical College Hospital, Chinese Academy of Medical Sciences  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