{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T04:53:11Z","timestamp":1781585591299,"version":"3.54.5"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003693","name":"Korea Institute of Science and Technology","doi-asserted-by":"publisher","award":["2E33742"],"award-info":[{"award-number":["2E33742"]}],"id":[{"id":"10.13039\/501100003693","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pancreatic cancer remains a highly lethal malignancy due to late diagnosis and the lack of effective non\u2010invasive biomarkers for detection, further complicated by biological heterogeneity, including intraductal papillary mucinous neoplasm (IPMN) and IPMN\u2010associated invasive carcinoma (IPMC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Serum samples from a discovery cohort (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200960), including patients with IPMN, IPMC, and pancreatic ductal adenocarcinoma (PDAC), were analyzed using LC\u2013MS\/MS\u2010based serum proteomic profiling to identify candidate biomarkers. Feature selection was performed using ANOVA, receiver operating characteristic analysis, and permutation feature importance. The selected markers were further evaluated in an independent validation cohort (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200940).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In the discovery cohort, the model demonstrated robust performance, with leave\u2010one\u2010out cross\u2010validation AUROC values ranging from 0.814 to 1.000 across classifications of healthy controls and disease groups (IPMN, IPMC, and PDAC). In the independent validation cohort, the six\u2010marker panel (CALR, FCN1, MBL2, SPP1, TAGLN2, and VWF) achieved an AUROC of 0.962 with a specificity of 95.0% for distinguishing healthy controls from IPMC, and an AUROC of 0.856 with a specificity of 90.0% for healthy controls vs. PDAC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings demonstrate the robustness and clinical potential of the six\u2010protein panel as a non\u2010invasive diagnostic tool for pancreatic cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71941","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T06:25:57Z","timestamp":1778826357000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mass Spectrometry\u2010Driven Proteomic Biomarkers for Serum\u2010Based Detection of Pancreatic Ductal Adenocarcinoma and Intraductal Papillary Mucinous Neoplasm\u2010Associated Invasive Carcinoma"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4306-6304","authenticated-orcid":false,"given":"HyunGyo","family":"Jung","sequence":"first","affiliation":[{"name":"Center for Advanced Biomolecular Recognition, Biomedical Research Institute Korea Institute of Science and Technology  Seoul Republic of Korea"},{"name":"Division of Bio\u2010Medical Science &amp; Technology, KIST School University of Science and Technology  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3947-4532","authenticated-orcid":false,"given":"Namyoung","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Bundang Hospital, Seoul National University College of Medicine  Seongnam Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0693-1415","authenticated-orcid":false,"given":"Jaihwan","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Bundang Hospital, Seoul National University College of Medicine  Seongnam Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1398-2037","authenticated-orcid":false,"given":"Min\u2010Jung","family":"Kang","sequence":"additional","affiliation":[{"name":"Center for Advanced Biomolecular Recognition, Biomedical Research Institute Korea Institute of Science and Technology  Seoul Republic of Korea"},{"name":"Division of Bio\u2010Medical Science &amp; Technology, KIST School University of Science and Technology  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,14]]},"reference":[{"key":"e_1_2_13_2_1","unstructured":"SEER Program. 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