{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T04:53:46Z","timestamp":1781585626964,"version":"3.54.5"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Continuous venetoclax\u2010azacitidine (VA) therapy is currently the major intervention for elderly or unfit acute myeloid leukemia (AML) patients. However, moderate chemotherapy with finite\u2010duration VA could achieve comparable or superior efficacy to infinite\u2010duration VA. Additionally, umbilical cord blood (UCB) transfusion improves clinical safety for elderly patients. Therefore, this single\u2010center study presents an improved approach: A finite\u2010duration VA and decitabine priming with intermediate\u2010dose cytarabine followed by UCB infusion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We included elderly AML patients who underwent the treatment between March 2021 and May 2024. Induction and maintenance regimens were VA. Our consolidation therapy involved intravenous decitabine (20\u2009mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      d1\u20133), intermediate\u2010dose cytarabine (1.0\u2009g\/m\n                      <jats:sup>2<\/jats:sup>\n                      q12h d4\u20135), with subsequent UCB infusion (1.5%\u2009\u00b1\u200925%\u2009\u00d7\u200910\n                      <jats:sup>7<\/jats:sup>\n                      \/kg) d7. Our endpoints included duration of response (DOR), overall survival (OS), and safety.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We analyzed 16 patients with a median follow\u2010up of 53.6\u2009months (95% CI: 36.2\u201371.0\u2009months), and 7 out of 16 participants were at adverse risk. The median VA cycle number prior to disease relapse was 5 (IQR: 4\u20136). The median DOR was 17.4\u2009months (95% CI: 7.3\u201327.5\u2009months), with a 1\u2010year DOR rate of 68.8% and a 2\u2010year DOR rate of 35.2%. The median OS was 24.9\u2009months (95% CI: 9.8\u201340.1\u2009months), with a 1\u2010 and 2\u2010year OS rate of 100% and 55.6%. Specifically, among the 8 patients with IDH1\/2 mutations, 4 experienced sustained remission, with 1\u2010year OS of 100%. Hematological and non\u2010hematological toxicities remained manageable during the consolidation phase.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We demonstrated prolonged survival, particularly in patients with IDH mutations, using the modified intervention. This approach holds significant value for elderly patients with untreated AML who are unfit for standard treatments.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71943","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T07:12:31Z","timestamp":1779174751000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Finite\u2010Duration Venetoclax\/Azacitidine Followed by Umbilical Cord Blood Infusion Improves Outcomes in Frail Elderly Patients With Untreated Acute Myeloid Leukemia\u2014A Pilot Study"],"prefix":"10.1002","volume":"15","author":[{"given":"Li","family":"Ye","sequence":"first","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital, Zhejiang University School of Medicine  Hangzhou People's Republic of China"},{"name":"Zhejiang Provincial Key Laboratory of Hematopoietic Malignancy Zhejiang University  Zhejiang Hangzhou People's Republic 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