{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T04:53:18Z","timestamp":1781585598760,"version":"3.54.5"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Lenvatinib is approved as a first\u2010line treatment for unresectable hepatocellular carcinoma (HCC), but real\u2010world outcomes may vary due to patient heterogeneity. This study aimed to evaluate the real\u2010world efficacy of lenvatinib in Taiwanese patients and to identify prognostic factors influencing outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study included 111 patients with unresectable HCC treated with the first\u2010line lenvatinib between February 2020 and April 2023 at Taichung Veterans General Hospital. All patients were Child\u2010Pugh class A and had at least one measurable lesion per mRECIST. Radiological tumor response, overall survival (OS), and progression\u2010free survival (PFS) were recorded and analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The ORR and DCR were 36% and 81% respectively. The median OS of all patients was 17\u2009months, and PFS was 10\u2009months. Patients with ALBI grade 1 (HR 0.45, 95% CI 0.24\u20130.84,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.011) and receiving combined locoregional therapy (LRT) (HR 0.38, 95% CI 0.20\u20130.79,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003) had significantly longer OS. AFP \u2264\u2009400\u2009ng\/mL was associated with longer PFS (HR 0.35, 95% CI 0.35\u20130.94,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.028).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Lenvatinib is effective in real\u2010world treatment of unresectable HCC, especially when combined with LRT. ALBI grade 1 and AFP \u2264\u2009400\u2009ng\/mL are favorable prognostic indicators for survival and disease control. These findings support personalized treatment strategies and warrant further prospective validation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71944","type":"journal-article","created":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T06:09:07Z","timestamp":1778911747000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Real\u2010World Experience of Prognostic Factors of Survival Outcomes in a Taiwanese Population With Unresectable Hepatocellular Carcinoma Treated With First\u2010Line Lenvatinib"],"prefix":"10.1002","volume":"15","author":[{"given":"Shou\u2010Wu","family":"Lee","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Taichung Veterans General Hospital  Taichung Taiwan"},{"name":"Department of Internal Medicine Chung Shan Medical University  Taichung Taiwan"},{"name":"Department of Post\u2010Baccalaureate Medicine, College of Medicine National Chung Hsing University  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Jie","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Taichung Veterans General Hospital  Taichung Taiwan"},{"name":"Department of Internal Medicine National Yang Ming Chiao Tung University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsin\u2010Ju","family":"Tsai","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Taichung Veterans General Hospital  Taichung Taiwan"},{"name":"Department of Post\u2010Baccalaureate Medicine, College of Medicine National Chung Hsing University  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying\u2010Cheng","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Taichung Veterans General Hospital  Taichung Taiwan"},{"name":"Department of Post\u2010Baccalaureate Medicine, College of Medicine National Chung Hsing University  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia\u2010Chang","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Taichung Veterans General Hospital  Taichung Taiwan"},{"name":"Department of Post\u2010Baccalaureate Medicine, College of Medicine National Chung Hsing University  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teng\u2010Yu","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Taichung Veterans General Hospital  Taichung Taiwan"},{"name":"Department of Internal Medicine Chung Shan Medical University  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yen","family":"Chun\u2010Peng","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Taichung Veterans General Hospital  Taichung Taiwan"},{"name":"Department of Internal Medicine National Yang Ming Chiao Tung University  Taipei 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Response Predicts Treatment Outcomes in Patients With Unresectable Hepatocellular Carcinoma Receiving Immune Checkpoint Inhibitors With or Without Tyrosine Kinase Inhibitors or Locoregional Therapies","volume":"11","author":"Hsu W. 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