{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T04:53:47Z","timestamp":1781585627009,"version":"3.54.5"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The role of carboplatin in neoadjuvant chemotherapy for triple\u2010negative breast cancer (TNBC) remains controversial, particularly in settings where access to immunotherapy is limited. This study evaluated the real\u2010world impact of adding carboplatin to neoadjuvant chemotherapy on pathological complete response (pCR) and survival outcomes in patients with TNBC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective multicenter study included patients with nonmetastatic TNBC treated with neoadjuvant anthracycline\u2010 and taxane\u2010based chemotherapy between 2018 and 2023 at three oncology centers in Turkey. Patients were grouped according to receipt of platinum\u2010containing therapy. Survival outcomes were estimated using the Kaplan\u2013Meier method and compared with the log\u2010rank test. Cox regression analyses were performed to evaluate factors associated with survival. Propensity score matching was also performed as a supportive analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 142 patients were included, of whom 45 (32.2%) received platinum\u2010containing neoadjuvant chemotherapy. Overall, 80 patients (56.3%) achieved pCR. The pCR rate was significantly higher in the platinum group than in the non\u2010platinum group (68.9% vs. 50.5%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.031). After a median follow\u2010up of 57\u2009months, 24 deaths and 33 DFS events were observed. Median OS and DFS were not reached. The 60\u2010month OS rate was 96.0% in the platinum group and 73.9% in the non\u2010platinum group (log\u2010rank\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.027), whereas the 60\u2010month DFS rates were 86.1% and 67.6%, respectively (log\u2010rank\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.139). Patients who achieved pCR had significantly better OS and DFS than those with residual disease. In the propensity score\u2010matched cohort, non\u2010platinum treatment remained associated with inferior OS and DFS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this multicenter real\u2010world cohort, carboplatin was associated with a higher pCR rate and numerically favorable survival outcomes. These findings may be clinically relevant where immunotherapy is not readily accessible but should be considered hypothesis\u2010generating and require prospective validation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71951","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T08:21:42Z","timestamp":1779351702000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multicenter Real\u2010World Evaluation of Neoadjuvant Carboplatin in Triple\u2010Negative Breast Cancer"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9593-0942","authenticated-orcid":false,"given":"Halil \u0130brahim","family":"Ellez","sequence":"first","affiliation":[{"name":"Departmant of Medical Oncology Sanl\u0131urfa Mehmet Akif \u0130nan Education and Research Hospital, University of Health Sciences  Sanl\u0131urfa T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0785-0238","authenticated-orcid":false,"given":"Eda","family":"\u00c7ali\u015fkanYildirim","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Sincan Education and Research Hospital  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2575-5819","authenticated-orcid":false,"given":"Nargiz","family":"Majidova","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology VM Medical Park Maltepe Hospital  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4409-6003","authenticated-orcid":false,"given":"Ye\u015fim","family":"A\u011fyol","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Medical Oncology Marmara University  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0596-1559","authenticated-orcid":false,"given":"Murat","family":"Sar\u0131","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Medical Oncology Marmara University  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7083-8517","authenticated-orcid":false,"given":"H\u00fcseyin Salih","family":"Semiz","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Institute of Oncology Dokuz Eylul University  Izm\u0131r T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3540-0701","authenticated-orcid":false,"given":"Oktay Halit","family":"Aktepe","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Institute of Oncology Dokuz Eylul University  Izm\u0131r T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7698-3574","authenticated-orcid":false,"given":"Ol\u00e7un Umit","family":"Unal","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Izmir City Hospital  Izm\u0131r T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2803-9287","authenticated-orcid":false,"given":"Elif","family":"Ata\u011f","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Institute of Oncology Dokuz Eylul University  Izm\u0131r 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