{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T11:04:16Z","timestamp":1784199856004,"version":"3.55.0"},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:00:00Z","timestamp":1779753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:00:00Z","timestamp":1779753600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100018904","name":"Beijing Xisike Clinical Oncology Research Foundation","doi-asserted-by":"publisher","award":["Y\u2010Gilead2024\u2010PT\u2010029"],"award-info":[{"award-number":["Y\u2010Gilead2024\u2010PT\u2010029"]}],"id":[{"id":"10.13039\/100018904","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Metronomic chemotherapy (mCHT) is widely used in the treatment of breast cancer due to its low toxicity and convenience. However, there remain real\u2010world studies with satisfactory samples focusing on mCHT in advanced breast cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Enrolled patients were assigned into capecitabine\u2010based (X\u2010based) group and other mCHT group. Data on baseline characteristics, treatment regimens, and outcomes were extracted from medical records. Kaplan\u2013Meier estimates of progression\u2010free survival (PFS) and overall survival (OS) were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Totally, 597 patients were included with median follow\u2010up time of 35.9\u2009months. The median PFS for X\u2010base group was significantly higher than that in other mCHT group (8.9 vs. 5.9\u2009months,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004). As salvage therapy, the X\u2010based group showed significantly higher PFS and OS than the other mCHT group in patients with HR\u2009+\u2009HER2\u2010 breast cancer (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001 and\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.011), especially in those combined with endocrine therapy (ET). Multivariate Cox analysis revealed that additional ET could reduce the disease progression and death risks (HR\u2009=\u20090.60, 95% CI: 0.44\u20130.81; HR\u2009=\u20090.66, 95% CI: 0.47\u20130.93). In HER2+ and TNBC populations, the median PFS was higher when used as maintenance therapy compared to salvage therapy (16.0 vs. 7.0\u2009months,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001; 11.0 vs. 5.0\u2009months,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.030).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>As salvage therapy, mCHT demonstrated significant efficacy advantages in the X\u2010based group compared to the other mCHT group in patients with HR\u2009+\u2009HER2\u2010 breast cancer, especially in those combined with ET. For HER2+ and TNBC patients, mCHT is recommended as maintenance therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71961","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T10:46:49Z","timestamp":1779792409000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Real\u2010World Efficacy of Metronomic Chemotherapy in Advanced Breast Cancer Across Molecular Subtypes"],"prefix":"10.1002","volume":"15","author":[{"given":"Hanxing","family":"Zhou","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Department of Medical Oncology Sun Yat\u2010Sen University Cancer Center  Guangzhou Guangdong China"},{"name":"Department of Medical Oncology Sun Yat\u2010Sen University Cancer Center  Guangzhou Guangdong China"},{"name":"Department of Medical Oncology The Seventh Affiliated 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