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This study aimed to identify genetic variants associated with PCa in a Taiwanese cohort and to explore their potential biological relevance using integrative annotation approaches.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed 961 PCa patients and 3792 age\u2010matched controls from the Taiwan Biobank. Genotyping and imputation were performed using the Taiwan Biobank 2.0 array and the 1000 Genomes East Asian reference panel. Association testing was conducted using logistic regression adjusted for age and population structure. Gene\u2010based analysis using Multi\u2010marker Analysis of GenoMic Annotation (MAGMA), functional annotation using HaploReg, and prostate tissue cis\u2010expression quantitative trait loci (cis\u2010eQTL) and splicing QTL (sQTL) evaluation using the Genotype\u2010Tissue Expression project (GTEx) were performed to explore functional relevance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We identified 371 genome\u2010wide significant variants and 47 independent risk loci, including established regions (8q24.21,\n                      <jats:italic>ZNF365<\/jats:italic>\n                      ,\n                      <jats:italic>NCOR2<\/jats:italic>\n                      , and\n                      <jats:italic>PRKCB<\/jats:italic>\n                      ) as well as loci not previously reported in major GWAS (\n                      <jats:italic>CCDC36<\/jats:italic>\n                      ,\n                      <jats:italic>RAB6B<\/jats:italic>\n                      ,\n                      <jats:italic>TTLL3<\/jats:italic>\n                      , and\n                      <jats:italic>PARD3B<\/jats:italic>\n                      ). MAGMA analysis identified 80 PCa\u2010associated genes, and pathway analysis highlighted sphingolipid metabolism and leukocyte transendothelial migration. Integrative annotation indicated that several variants are located in regulatory elements and are associated with prostate\u2010specific eQTL and sQTL effects. Additional analyses showed that several variants were associated with clinical indicators of disease aggressiveness, and age\u2010stratified sensitivity analyses demonstrated consistent associations across age groups. Sensitivity analyses using alternative modeling approaches yielded comparable results.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study identifies both established and putatively novel genetic loci associated with PCa in a Taiwanese cohort and provides functional insights through integrative annotation. These findings contribute to understanding the genetic architecture of PCa in East Asian populations and highlight candidate loci that require independent validation in future studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71971","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T04:27:33Z","timestamp":1783484853000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploring Genetic Contributions to Prostate Cancer Risk in an Asian Population\u2010Based Study"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0610-1278","authenticated-orcid":false,"given":"Jiun\u2010Hung","family":"Geng","sequence":"first","affiliation":[{"name":"Graduate Institute of Clinical Medicine, College of Medicine Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"Department of Urology Kaohsiung Municipal Siaogang Hospital  Kaohsiung Taiwan"},{"name":"Department of Urology Kaohsiung Medical University Hospital, Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"Department of Urology, Faculty of Post\u2010Baccalaureate Medicine, College of Medicine Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"Center for Big Data Research Kaohsiung Medical University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia\u2010Cheng","family":"Yu","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery Kaohsiung Veterans General Hospital  Kaohsiung Taiwan"},{"name":"Department of Urology, School of Medicine National Yang Ming Chiao Tung University  Taipei Taiwan"},{"name":"Department of Pharmacy Tajen University  Pingtung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao\u2010Yuan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Urology, College of Medicine National Taiwan University Hospital, National Taiwan University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0075-7014","authenticated-orcid":false,"given":"Victor C.","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Urology E\u2010Da Hospital  Kaohsiung Taiwan"},{"name":"School of Medicine for International Students I\u2010Shou University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5689-9850","authenticated-orcid":false,"given":"Chia\u2010Yang","family":"Li","sequence":"additional","affiliation":[{"name":"Graduate Institute of Medicine, College of Medicine Kaohsiung Medical University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Tsang","family":"Wu","sequence":"additional","affiliation":[{"name":"Environmental and Occupational Medicine, College of Medicine Kaohsiung Medical University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1610-4184","authenticated-orcid":false,"given":"Szu\u2010Chia","family":"Chen","sequence":"additional","affiliation":[{"name":"Center for Big Data Research Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"Department of Internal Medicine Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"Department of Internal Medicine, Division of Nephrology Kaohsiung Medical University Hospital, Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"Faculty of Medicine, College of Medicine Kaohsiung Medical University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo\u2010Ying","family":"Bao","sequence":"additional","affiliation":[{"name":"Department of Pharmacy China Medical University  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu\u2010Pin","family":"Huang","sequence":"additional","affiliation":[{"name":"Graduate Institute of Clinical Medicine, College of Medicine Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"Department of Urology Kaohsiung Medical University Hospital, Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"Institute of Medical Science and Technology, College of Medicine National Sun Yat\u2010Sen University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,7]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_11_3_1","unstructured":"Health Promotion Administration Ministry of Health and Welfare. 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