{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T04:53:25Z","timestamp":1781585605063,"version":"3.54.5"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T00:00:00Z","timestamp":1779408000000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study compares demographics and geographic factors associated with access to chimeric antigen receptor (CAR)\u2010T cell therapy for B\u2010cell malignancies or multiple myeloma: individuals in clinical trials at the University of Kansas Cancer Center (KUCC) and those receiving standard\u2010of\u2010care (SOC) CAR\u2010T at the University of Kansas Health System (TUKHS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data were collected from electronic medical records and the KUCC Clinical Trial Management System. We evaluated differences in CAR\u2010T access across race, gender, age, rurality, and HPSA status. SOC patients received FDA\u2010approved CAR\u2010T between May 2021 and May 2023; clinical trial patients received investigational CAR\u2010T between January 2015 and February 2023.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Most patients (80%) were from urban areas; 54.1% lived within 50\u2009miles of the University of Kansas Medical Center (KUMC). The cohort was 58.4% male, 86.7% white, 60.4% aged 19\u201364, and 57% lived outside a Health Professional Shortage Area (HPSA). Rural patients made up 20% of both cohorts. No significant demographic differences were observed between clinical trial and SOC recipients. However, rural residence was significantly associated with age 65 or older (OR\u2009=\u20091.80), white race, HPSA status, and living more than 50\u2009miles from KUMC (OR\u2009=\u200927.01). HPSA status was also associated with greater odds of living beyond the 50\u2010mile radius (OR\u2009=\u20092.29).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Findings highlight important geographic disparities in CAR\u2010T access. Targeted outreach to rural and HPSA\u2010designated communities may improve equity and ensure broader access to advanced therapies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71974","type":"journal-article","created":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T03:54:56Z","timestamp":1779508496000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Geographic Disparities Analysis Between Standard of Care and Clinical Trial\n                    <scp>CAR<\/scp>\n                    \u2010T Patients in Kansas"],"prefix":"10.1002","volume":"15","author":[{"given":"Sam","family":"Pepper","sequence":"first","affiliation":[{"name":"Department of Biostatistics &amp; Data Science The University of Kansas Medical Center  Kansas City Kansas USA"},{"name":"University of Kansas Cancer Center  Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aliya","family":"Rashid","sequence":"additional","affiliation":[{"name":"University of Kansas Medical Center Division of Hematologic Malignancies &amp; Cellular Therapeutics  Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carine","family":"Tabak","sequence":"additional","affiliation":[{"name":"University of Kansas Medical Center Division of Hematologic Malignancies &amp; Cellular Therapeutics  Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isuru","family":"Ratnayake","sequence":"additional","affiliation":[{"name":"Department of Biostatistics &amp; Data Science The University of Kansas Medical Center  Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammod Mahmudur","family":"Rahman","sequence":"additional","affiliation":[{"name":"Department of Biostatistics &amp; Data Science The University of Kansas Medical Center  Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Robiul Islam","family":"Talukder","sequence":"additional","affiliation":[{"name":"Department of Biostatistics &amp; Data Science The University of Kansas Medical Center  Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"McGuirk","sequence":"additional","affiliation":[{"name":"Department of Biostatistics &amp; Data Science The University of Kansas Medical Center  Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Rippee","sequence":"additional","affiliation":[{"name":"Department of Biostatistics &amp; Data Science The University of Kansas Medical Center  Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"McGuirk","sequence":"additional","affiliation":[{"name":"University of Kansas Cancer Center  Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Kansas Medical Center  Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony D.","family":"Sung","sequence":"additional","affiliation":[{"name":"University of Kansas Medical Center Division of Hematologic Malignancies &amp; Cellular Therapeutics  Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nausheen","family":"Ahmed","sequence":"additional","affiliation":[{"name":"University of Kansas Medical Center Division of Hematologic Malignancies &amp; Cellular Therapeutics  Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinesh Pal","family":"Mudaranthakam","sequence":"additional","affiliation":[{"name":"Department of Biostatistics &amp; Data Science The University of Kansas Medical Center  Kansas City Kansas USA"},{"name":"University of Kansas Cancer Center  Kansas City Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,22]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"S. S.Neelapu \u201cTargeted Oncology \u201d2022 https:\/\/www.targetedonc.com\/view\/many\u2010challengesopportunities\u2010for\u2010car\u2010t\u2010cell\u2010therapies\u2010in\u2010lymphoma%202022."},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2022.04.008"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2024.04.017"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2024.01.006"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/CCI.24.00099"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2023.04.003"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2023012549"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2024024959"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2024013148"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conctc.2016.12.004"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.2217\/imt\u20102020\u20100181"},{"key":"e_1_2_11_13_1","unstructured":"U.S. Department of Agriculture Economic Research Service Rural\u2010Urban Continuum Codes January 2024 https:\/\/www.ers.usda.gov\/data\u2010products\/rural\u2010urban\u2010continuum\u2010codes\/."},{"key":"e_1_2_11_14_1","unstructured":"U.S. Department of Agriculture State Fact Sheets Kansas https:\/\/www.ers.usda.gov\/data\u2010products\/state\u2010fact\u2010sheets.aspx."},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.2196\/33240"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/database\/baaa054"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACM.0000000000001612"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2023.03.021"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2023.41.16_suppl.e18633"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.simpa.2021.100099"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2015\u20100110"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.ss6614a1"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a113002"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a116774"},{"key":"e_1_2_11_25_1","volume-title":"Kansas Statistical Abstract 2023","author":"Kansas Data Access and Support Center","year":"2023"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2024.1397613"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2024015634"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.71974","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cam4.71974","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.71974","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T04:10:26Z","timestamp":1781583026000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.71974"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":26,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1002\/cam4.71974"],"URL":"https:\/\/doi.org\/10.1002\/cam4.71974","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"2025-04-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71974"}}