{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T04:53:13Z","timestamp":1781585593258,"version":"3.54.5"},"reference-count":45,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T00:00:00Z","timestamp":1779408000000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100017268","name":"Berlin Institute of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["493872418"],"award-info":[{"award-number":["493872418"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Deep learning (DL) methods may enhance analysis of complex gene expression data to aid in diagnosis and treatment planning for pediatric extracranial tumors. However, the literature regarding the application of DL to gene expression data in this field remains limited. This scoping review was based on the question \u201cWhat is the current status of research in gene expression, gene\u2010related information and deep learning\u2010based analyses for pediatric surgical oncology\n                    <jats:italic>\u201d<\/jats:italic>\n                    . We conducted a scoping review in accordance with the PRISMA\u2010ScR guidelines. A systematic search of PubMed, Scopus, and Embase was performed to identify studies applying DL models to gene\u2010related data in pediatric extracranial solid tumors. After deduplication, title and abstract screening and full\u2010text screening, nine studies met the inclusion criteria. Neuroblastoma was the most commonly studied tumor type (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20096), with classification and survival prediction as applications. In general, the studies reported strong performance; however, external validation was rarely reported. Although the application of DL to gene\u2010related data in pediatric solid tumors remains in its infancy, current studies highlight the diversity and potential of approaches that could improve classification, prognostication, and the treatment of patients. The large variety of technical approaches reflects the ongoing process of adaptation to gene\u2010related data. Advancing this field will require larger datasets, consistent methodology, external, and prospective validation within a cross\u2010disciplinary setting.\n                  <\/jats:p>","DOI":"10.1002\/cam4.71976","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T07:39:08Z","timestamp":1779435548000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Deep Learning\u2010Based Analysis of Gene Expression Data and Gene\u2010Related Information in Pediatric Surgical Oncology: A Scoping Review"],"prefix":"10.1002","volume":"15","author":[{"given":"Simon","family":"Berhe","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery Charit\u00e9\u2010Universit\u00e4tsmedizin  Berlin Germany"},{"name":"Max Delbr\u00fcck Center for Molecular Medicine in the Helmholtz Association (MDC)  Berlin Germany"},{"name":"Berlin Institute of Health at Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen E.","family":"Fuchs","sequence":"additional","affiliation":[{"name":"Berlin Institute of Health at Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin  Berlin Germany"},{"name":"Department of Pediatric Oncology and Hematology Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin  Berlin Germany"},{"name":"German Cancer Consortium (DKTK), partner Site Berlin, a Partnership Between DKFZ and Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Altuna","family":"Akalin","sequence":"additional","affiliation":[{"name":"Max Delbr\u00fcck Center for Molecular Medicine in the Helmholtz Association (MDC)  Berlin Germany"},{"name":"Bioinformatics and Omics Data Science Platform  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alida F. W.","family":"van der Steeg","sequence":"additional","affiliation":[{"name":"Princess M\u00e1xima Center for Pediatric Oncology  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven W.","family":"Warmann","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Charit\u00e9\u2010Universit\u00e4tsmedizin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0640-6434","authenticated-orcid":false,"given":"Myrthe A. D.","family":"Buser","sequence":"additional","affiliation":[{"name":"Princess M\u00e1xima Center for Pediatric Oncology  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moritz","family":"Markel","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Charit\u00e9\u2010Universit\u00e4tsmedizin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,22]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djad115"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.00278"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571\u2010022\u201000643\u2010z"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010023\u201037714\u20109"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6471169"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201039717\u20106"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.28987"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s43556\u2010025\u201000263\u2010w"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416\u2010024\u201002856\u20108"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201095969\u20106"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41563\u2010019\u20100360\u20101"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s42979\u2010021\u201000815\u20101"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/CANCERS15072115"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.70574"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.media.2017.07.005"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/RCT.0000000000001480"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.CCR\u201014\u20100817"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.26508\/lsa.201900517"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.7326\/M18\u20100850"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42256\u2010020\u201000287\u20107"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prime.2023.100233"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102105\u201013\u2010S4\u2010S13"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.653863"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm13030447"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102105\u20108\u20105"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.5808\/GI.2019.17.3.e30"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2023.1238095"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12920\u2010019\u20100628\u2010y"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1080\/15513815.2023.2242979"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/NRDP.2016.78"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967\u2010016\u20100896\u20107"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201063688\u20105"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.30342"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.21037\/QIMS\u201022\u20101042\/COIF"},{"key":"e_1_2_12_36_1","doi-asserted-by":"crossref","unstructured":"F. 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