{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T23:19:07Z","timestamp":1785799147462,"version":"3.56.0"},"reference-count":46,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,24]],"date-time":"2026-05-24T00:00:00Z","timestamp":1779580800000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82101186"],"award-info":[{"award-number":["82101186"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2021A1515011127"],"award-info":[{"award-number":["2021A1515011127"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2022A1515012394"],"award-info":[{"award-number":["2022A1515012394"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Biologics targeting Type 2 immune responses, such as omalizumab (anti\u2010IgE), dupilumab (anti\u2010interleukin\u20104 receptor alpha, anti\u2010IL\u20104R\u03b1), benralizumab (anti\u2010IL\u20105R), reslizumab, and mepolizumab (anti\u2010IL\u20105), are increasingly used clinically. Emerging evidence suggests potential associations between biologics and neoplastic events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed the FDA Adverse Event Reporting System (FAERS) database reports for omalizumab, dupilumab, benralizumab, reslizumab, and mepolizumab from their respective market dates to Q1 2025. To enhance comparability, this analysis was restricted to the asthma indication for all 5 biologics. Neoplasm\u2010related adverse events (AEs) were assessed using disproportionality analysis and multivariable logistic regression analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 2316 neoplasm\u2010related AE reports were identified (974 omalizumab, 322 dupilumab, 369 benralizumab, and 651 mepolizumab). Increased reporting may reflect higher biologic use, reporting biases, or system inherent biases. The most common neoplasms reported for omalizumab, dupilumab, benralizumab, and mepolizumab were breast cancer (13.23%, 15.25%, 14.9%, 9.21%), malignant lung neoplasm (5.86%, 5.28%, 5.56%, 6.74%), and prostate cancer (3.29%, 5.87%, 3.54%, 5.06%). All biologics had significant disproportionality signals. Despite low reporting frequency, several neoplasms demonstrated strong signals with biologics of interest. Notably, dupilumab exhibited a strong and specific signal for cutaneous T\u2010cell lymphoma (ROR\u2009=\u20096.1, 95% CI: 1.76\u201321.06). Similar patterns were likewise observed in the multivariable logistic regression analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This pharmacovigilance study detected neoplasm\u2010related disproportionality signals for anti\u2010Type 2 biologics. Causality cannot be established due to spontaneous reporting limitations. Clinicians should be aware of these disproportionality signals and maintain vigilance during long\u2010term clinical management of patients receiving anti\u2010Type 2 biologic therapy to ensure optimal patient safety.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71979","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T05:19:45Z","timestamp":1779686385000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Neoplasm Adverse Events Associated With Anti\u2010Type 2 Biologics: An\n                    <scp>FAERS<\/scp>\n                    Database Pharmacovigilance Analysis Study"],"prefix":"10.1002","volume":"15","author":[{"given":"Wen","family":"Lyu","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, the First Affiliated Hospital Sun Yat\u2010sen University  Guangzhou Guangdong China"},{"name":"Department of Allergy, the First Affiliated 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