{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:23:33Z","timestamp":1790231013144,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"21","license":[{"start":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T00:00:00Z","timestamp":1730246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30\u2010CA008748"],"award-info":[{"award-number":["P30\u2010CA008748"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Fatigue and sleep disorders are prevalent in cancer patients. Obstructive sleep apnea (OSA) commonly causes excessive daytime sleepiness (EDS) and fatigue. We hypothesize that treating cancer patients with OSA using positive airway pressure (PAP) will improve EDS and fatigue.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective chart review of sleep clinic visits of cancer patients with newly diagnosed OSA was performed. Epworth Sleepiness Scale (ESS) and fatigue reported at baseline and within 6\u2009months of starting PAP therapy were compared between PAP\u2010adherent and PAP\u2010non\u2010adherent patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      65 cancer patients with OSA and ESS &gt;10 were recommended PAP therapy, including 45 patients with fatigue. 29 patients pursued PAP therapy with 79% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200923) adherent at follow\u2010up. The median baseline apnea hypopnea index (AHI) for OSA was 24.0 (interquartile range [IQR] 14.3, 32.3) and 23.8 (IQR 10.1, 42.8) events\/hour among PAP\u2010adherent and PAP\u2010non\u2010adherent patients, respectively (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.90). Median baseline ESS was 14.0 (IQR 12.0, 17.0) among adherent and 17.0 (IQR 11.0, 17.3) among non\u2010adherent patients (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.73). The median ESS at follow\u2010up of the adherent and non\u2010adherent groups was 8.0 (IQR 6.0, 10.0) and 11.0 (IQR 8.0, 15.8), respectively (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.08). Median ESS change was \u22125.0 (IQR \u22127.0, \u22124.0) in PAP adherent patients and \u22122.5 (IQR \u22125.25, \u22121.50) in PAP\u2010non\u2010adherent patients (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.07). When the groups are examined separately, the median change in the PAP\u2010adherent group was highly significant (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001), while the ESS median change in the PAP\u2010non\u2010adherent group was considerably less (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04). 17\u00a0out of the 21 PAP\u2010adherent patients reporting fatigue at baseline indicated improvement at follow\u2010up.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>PAP therapy for OSA in cancer patients improves EDS and fatigue. Larger studies are necessary to evaluate the efficacy of PAP in improving fatigue in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.7198","type":"journal-article","created":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T12:31:47Z","timestamp":1730291507000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Treatment of obstructive sleep apnea with CPAP improves daytime sleepiness and fatigue in cancer patients"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-2915-9699","authenticated-orcid":false,"given":"Kimia G.","family":"Ganjaei","sequence":"first","affiliation":[{"name":"Pulmonary Service, Department of Medicine Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen A.","family":"Wong","sequence":"additional","affiliation":[{"name":"Pulmonary Service, Department of Medicine Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiela M.","family":"Strauss","sequence":"additional","affiliation":[{"name":"NYU Rory Meyers College of Nursing  New York New York USA"},{"name":"Department of Nursing Research Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigrid V.","family":"Carlsson","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics Memorial Sloan Kettering Cancer Center  New York New York USA"},{"name":"Department of Surgery Memorial Sloan Kettering Cancer Center  New York New York USA"},{"name":"Department of Urology, Institute of Clinical Sciences Sahlgrenska Academy at University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Barton\u2010Burke","sequence":"additional","affiliation":[{"name":"Department of Nursing Research Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9277-0680","authenticated-orcid":false,"given":"Miranda","family":"Tan","sequence":"additional","affiliation":[{"name":"Pulmonary Service, Department of Medicine Memorial Sloan Kettering Cancer Center  New York New York USA"},{"name":"Division of Sleep Medicine, Department of Psychiatry Stanford University School of Medicine  Palo Alto California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,30]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph182111696"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-019-04834-w"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2021.07.025"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2014.0067"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2016.07.002"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.27497"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.170296"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.15"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-020-02151-9"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2014-0176"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-020-05428-7"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-020-06355-3"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/13510002.2023.2279813"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-58906-7"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11132051"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00036.2018"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arbres.2023.07.001"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.2310\/7070.2005.34502"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0249099"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000492273"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aes022"},{"key":"e_1_2_11_23_1","unstructured":"Centers for Medicare and Medicaid Services website.Decision Memo for Continuous Positive Airway Pressure (CPAP) Therapy for Obstructive Sleep Apnea (OSA) (CAG\u201000093N). 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