{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T11:03:10Z","timestamp":1784199790521,"version":"3.55.0"},"reference-count":71,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T00:00:00Z","timestamp":1781222400000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Exercise improves physical function and health\u2010related quality of life (HRQoL) in patients with cancer; however, nationwide structured programmes remain limited. A hospital in Germany implemented a donation\u2010funded Haematological and Oncological Training Therapy with Stationary Strength and Cardio Machines (HOT), and a 3\u2010year real\u2010world data analysis aimed to evaluate its acceptance, feasibility, safety, and effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>HOT comprised 24 sessions of combined resistance and aerobic training, complemented by a sensorimotor module for patients with chemotherapy\u2010induced peripheral neuropathy (CIPN), with a target frequency of two sessions per week. Patients with all cancer types and treatment phases were eligible. The study evaluated acceptance (e.g., participants' clinical and sociodemographic characteristics, reasons for premature discontinuation), feasibility (e.g., completion rate, training density), safety (adverse events), and effects (changes in strength [1\u2010repetition maximum, 1\u2010RM], cardiopulmonary performance [maximum power on a cycle ergometer], and patient\u2010reported outcomes [HRQoL, fatigue, CIPN]) within a quasi\u2010experimental pre\u2013post design.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Between April 2021 and March 2024, 70 patients (60% female; mean age, 63\u2009\u00b1\u200912\u2009years; range, 31\u201391\u2009years) participated; 61% had solid tumours and 39% haematological malignancies, and 57% were undergoing active cancer treatment. Most participants (94%) had a history of sports participation. A total of 53 participants (76%) completed HOT, while 17 (24%) discontinued prematurely, mainly for health\u2010related reasons. The training density among completers was 1.6 sessions per week. One adverse event occurred during a 1\u2010RM test. Significant improvements were observed in strength and cardiopulmonary performance (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), as well as in global HRQoL (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), fatigue (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and CIPN (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>HOT appeared to primarily attract sports\u2010experienced patients, with haematological malignancies overrepresented. HOT proved to be safe and feasible across diverse cancer entities and treatment phases and was associated with improvement in physical function and HRQoL. The participants' high baseline motivation for exercise may limit generalisability.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.72013","type":"journal-article","created":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T06:15:11Z","timestamp":1781331311000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Haematological and Oncological Training Therapy With Stationary Strength and Cardio Machines (\n                    <scp>HOT<\/scp>\n                    ) in Routine Cancer Care: A 3\u2010Year Real\u2010World Evaluation of Acceptance, Feasibility, Safety, and Effects"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4882-0468","authenticated-orcid":false,"given":"Sabine","family":"Felser","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Clinic for Hematology, Hemostaseology, Oncology, Stem Cell Therapy and Palliative Care Rostock University Medical Center  Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maya","family":"Engel","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Clinic for Hematology, Hemostaseology, Oncology, Stem Cell Therapy and Palliative Care Rostock University Medical Center  Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Grosse\u2010Thie","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Clinic for Hematology, Hemostaseology, Oncology, Stem Cell Therapy and Palliative Care Rostock University Medical Center  Rostock Germany"},{"name":"Hematology and Oncology Practice  Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Kragl","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Clinic for Hematology, Hemostaseology, Oncology, Stem Cell Therapy and Palliative Care Rostock University Medical Center  Rostock Germany"},{"name":"Oncology Centre of the Rostock University Medical Centre  Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa","family":"Henze","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Clinic for Hematology, Hemostaseology, Oncology, Stem Cell Therapy and Palliative Care Rostock University Medical Center  Rostock Germany"},{"name":"Department of Internal Medicine II\u2014Hematology, Oncology and Palliative Medicine Asklepios Hospital Harz  Goslar Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imke","family":"Albrecht","sequence":"additional","affiliation":[{"name":"Oncology Centre of the Rostock University Medical Centre  Rostock Germany"},{"name":"Department of Physiotherapy Rostock University Medical Center  Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Lampe","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Clinic for Hematology, Hemostaseology, Oncology, Stem Cell Therapy and Palliative Care Rostock University Medical Center  Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Fischer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Clinic for Hematology, Hemostaseology, Oncology, Stem Cell Therapy and Palliative Care Rostock University Medical Center  Rostock Germany"},{"name":"Mittelstand\u2010Digital Zentrum Rostock, Stabsstelle \u00c4rztlicher Vorstand Rostock University Medical Center  Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Langenkamp","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Clinic for Hematology, Hemostaseology, Oncology, Stem Cell Therapy and Palliative Care Rostock University Medical Center  Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Junghanss","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Clinic for Hematology, Hemostaseology, Oncology, Stem Cell Therapy and Palliative Care Rostock University Medical Center  Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,12]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2017-097891"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2024.1393902"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu9091003"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-022-07389-5"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2023.1252259"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2024.2354"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jshs.2023.01.002"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-21-1258"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/epirev\/mxx007"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000002117"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2017.09.015"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/bmb\/ldab019"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000002116"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja18.00199"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21579"},{"key":"e_1_2_13_17_1","unstructured":"Bundesarbeitsgemeinschaft f\u00fcr Rehabilitation e. V \u201cRehabilitationssport und Funktionstraining: Rahmenvereinbarung \u201d accessed April 1 2026 https:\/\/www.bar\u2010frankfurt.de\/fileadmin\/dateiliste\/_publikationen\/reha_vereinbarungen\/vereinbarung\/downloads\/rahmenvereinbarung_ueber_den_rehabilitationssport_und_das_funktionstraining.pdf."},{"issue":"19","key":"e_1_2_13_18_1","first-page":"1457","article-title":"Onkologische Trainings\u2010 und Bewegungstherapie (OTT). [Evidence and Recommendations for Oncologic Clinical Exercise\u2014A Personalized Treatment Concept for Cancer Patients] [ger]","volume":"140","author":"Baumann F. T.","year":"2015","journal-title":"Deutsche medizinische Wochenschrift (1946)"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1519\/JSC.0000000000003230"},{"issue":"6","key":"e_1_2_13_20_1","first-page":"18","article-title":"Roundtable Discussion: Machines Versus Free Weights","volume":"22","author":"Haff G. G.","year":"2000","journal-title":"Strength and Conditioning Journal"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13102-023-00713-4"},{"key":"e_1_2_13_22_1","volume-title":"Bev\u00f6lkerungsdichte in Deutschland nach Bundesl\u00e4ndern zum 31","author":"Bundesamt S.","year":"2024"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.281053"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-022-07369-9"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1249\/00005768-198205000-00012"},{"issue":"24","key":"e_1_2_13_26_1","first-page":"409","article-title":"Exercise Testing in Sports Medicine","volume":"115","author":"L\u00f6llgen H.","year":"2018","journal-title":"Deutsches Arzteblatt International"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0838.2009.00985.x"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/85.5.365"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2022.10.026"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3999(94)00125-O"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1438.2003.13603.x"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.2466\/03.27.PMS.120v19x7"},{"key":"e_1_2_13_33_1","volume-title":"Robert Koch\u2010Institut und die Gesellschaft der epidemiologischen Krebsregister in Deutschland e.V. RKI\u2014Krebs in Deutschland f\u00fcr 2019\/2020","author":"Ronckers C\u00e9cile","year":"2023"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40798-026-00988-0"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/sms.14575"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-9057-1883"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-017-3827-0"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2018.03.026"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2024.1346099"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.59.1081"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13174478"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2022.6881"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.01958"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.62365"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0000000000000755"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-12-918"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2016-096537"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1080\/15412555.2021.1874897"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.5040\/9781492595632"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.2165\/00007256-200636020-00004"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.4081\/ejtm.2018.7590"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2007-0828"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(95)90040-3"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.13073"},{"issue":"5","key":"e_1_2_13_55_1","article-title":"The Power of Movement: How Exercise Influences Chemotherapy\u2010Induced Peripheral Neuropathy","volume":"13","author":"Loureiro J.","year":"2025","journal-title":"Biomedicine"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-023-02470-0"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.9.2381"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.66.4391"},{"key":"e_1_2_13_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70031-2"},{"key":"e_1_2_13_60_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2024-108671"},{"key":"e_1_2_13_61_1","doi-asserted-by":"publisher","DOI":"10.1093\/jncics\/pkz037"},{"key":"e_1_2_13_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2023.04.027"},{"key":"e_1_2_13_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11764-018-0711-y"},{"key":"e_1_2_13_64_1","volume-title":"ACSM's Complete Guide to Fitness & Health","author":"Bushman B. A.","year":"2017"},{"key":"e_1_2_13_65_1","first-page":"61","volume-title":"ACSM's Complete Guide to Fitness & Health","author":"Bushman B. A.","year":"2017"},{"key":"e_1_2_13_66_1","doi-asserted-by":"publisher","DOI":"10.1111\/ecc.13246"},{"key":"e_1_2_13_67_1","first-page":"1","article-title":"Exercise and Neuropathy","volume":"52","author":"Streckmann F.","year":"2021","journal-title":"Systematic Review With Meta\u2010Analysis. Sports Medicine"},{"key":"e_1_2_13_68_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11764-023-01450-w"},{"key":"e_1_2_13_69_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2015-094787"},{"key":"e_1_2_13_70_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.26463"},{"key":"e_1_2_13_71_1","unstructured":"J.Schneider K.Schl\u00fcter F.Rosenberger andJ.Wiskemann \u201cAre Percentages of the One\u2010Repetition Maximum (1\u2010RM) Suitable for Prescribing Resistance Exercise in Cancer Survivors?\u2014Comparability and Prediction Accuracy of Frequently Used 1\u2010RM Testing Procedures \u201d accessed May 3 2026 https:\/\/doi.org\/10.21203\/rs.3.rs\u20102165112\/v1."},{"key":"e_1_2_13_72_1","volume-title":"ACSM's Guidelines for Exercise Testing and Prescription","author":"Riebe D.","year":"2018"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.72013","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cam4.72013","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.72013","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T10:03:11Z","timestamp":1784196191000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.72013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":71,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/cam4.72013"],"URL":"https:\/\/doi.org\/10.1002\/cam4.72013","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"2025-08-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e72013"}}