{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:08:07Z","timestamp":1787314087204,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    To evaluate the comparative prognostic utility of next\u2010generation flow cytometry (NGF) and dual\u2010tracer PET\/CT in measuring minimal residual disease (MRD), this prospective real\u2010world study enrolled 118 newly diagnosed multiple myeloma (NDMM) patients. Patients underwent post\u2010treatment assessment using NGF (sensitivity 10\n                    <jats:sup>\u22125<\/jats:sup>\n                    ) and dual\u2010tracer PET\/CT using\n                    <jats:sup>11<\/jats:sup>\n                    C\u2010acetate (AC\u2010PET) and\n                    <jats:sup>18<\/jats:sup>\n                    F\u2010FDG. While AC\u2010PET showed a numerically higher detection rate compared to FDG\u2010PET in paired analyses (\n                    <jats:italic>n\u2009=<\/jats:italic>\n                    \u200945), a significant discordance was observed between imaging and immunophenotypic assessment. NGF detected MRD in 38.2% of paired cases compared to 11.8% by AC\u2010PET; however, AC\u2010PET uniquely identified metabolic activity in extramedullary sites for two NGF\u2010negative patients, highlighting the value of functional imaging in resolving spatial heterogeneity. In the landmark survival analysis (\n                    <jats:italic>n\u2009=<\/jats:italic>\n                    \u2009104), NGF positivity was identified as a robust independent predictor for inferior progression\u2010free survival (HR 2.21, 95% CI 1.01\u20134.81;\n                    <jats:italic>p\u2009=<\/jats:italic>\n                    \u20090.046) and overall survival (HR 4.97, 95% CI 1.23\u201320.01;\n                    <jats:italic>p\u2009=<\/jats:italic>\n                    \u20090.026), transcending baseline risk stratifications. Furthermore, longitudinal monitoring revealed that patients achieving sustained MRD negativity experienced significantly superior outcomes compared to those with transient negativity or persistent disease. These findings establish NGF as the standard prognostic biomarker for MM, while AC\u2010PET serves as a critical complementary tool for detecting extramedullary escape, supporting a risk\u2010adapted MRD strategy that integrates molecular depth with metabolic imaging.\n                  <\/jats:p>","DOI":"10.1002\/cam4.72023","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T04:06:28Z","timestamp":1781841988000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Prognostic Value of Next\u2010Generation Flow Cytometry Versus Dual\u2010Tracer\n                    <scp>PET<\/scp>\n                    \/\n                    <scp>CT<\/scp>\n                    for Minimal Residual Disease Assessment in Multiple Myeloma"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0206-318X","authenticated-orcid":false,"given":"Runfeng","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Hematology Peking Union Medical College Hospital, Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjia","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Peking Union Medical College Hospital Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0247-6829","authenticated-orcid":false,"given":"Lili","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Hematology Peking Union Medical College Hospital, Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Hematology Peking Union Medical College Hospital, Chinese Academy of Medical Sciences  Beijing China"},{"name":"Department of Psychological Medicine, Peking Union Medical College Hospital Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fujing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology Peking Union Medical College Hospital, Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiao","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Peking Union Medical College Hospital Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology Beijing Chao\u2010Yang Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Leng","sequence":"additional","affiliation":[{"name":"Department of Hematology Beijing Chao\u2010Yang Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Hematology Peking Union Medical College Hospital, Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Huo","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Peking Union Medical College Hospital Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junling","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Department of Hematology Peking Union Medical College Hospital, Chinese Academy of Medical Sciences  Beijing 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