{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T03:29:12Z","timestamp":1786418952107,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["2016\/04981\/ZONMW\u201091101002"],"award-info":[{"award-number":["2016\/04981\/ZONMW\u201091101002"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Inflammation\u2010related biomarkers have been implicated in a wide range of cancer\u2010related symptoms and patient\u2010reported outcomes (PROs), including fatigue, pain, and depression. To interpret biomarker data among cancer patients, normative reference values from healthy populations are essential.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This cross\u2010sectional study aimed to provide sex\u2010 and age\u2010stratified reference data distributions for 12 inflammation\u2010related serum biomarkers in a representative sample of Dutch adults without a history of cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Adults from the LISS panel were selected to match cancer cohorts from the PROFILES registry in age and sex. Participants completed questionnaires and optionally provided blood samples using harmonized protocols aligned with the PROFILES registry. Serum levels of IL\u20101\u03b1, IL\u20101\u03b2, IL\u20106, IL\u20108, IL\u201010, IL\u201017A, IL\u201022, CRP, TGF\u2010\u03b1, IFN\u2010\u03b3, IL\u20101RA, and soluble TNF receptors I and II (sTNFRI\/II) were quantified using the Meso Scale Discovery (MSD) platform. Cytokine levels were stratified by demographics, lifestyle factors, and self\u2010reported health conditions. ANOVAs were used to compare groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total 720 panel members filled out the questionnaires, of which 265 (mean age\u2009=\u200959.0, 47.9% male) provided additional serum blood samples. Biomarker levels varied by sex, age, BMI, smoking status, and number of health conditions. Notably, higher levels of IL\u20101RA and sTNFRI\/II were observed in individuals with obesity or diabetes. Individuals with osteoarthritis exhibited elevated IL\u20106 and IL\u20101\u03b2 levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study offers a robust reference dataset for key inflammatory biomarkers, stratified by relevant demographics, lifestyle factors, and self\u2010reported health conditions. These data facilitate interpretation of biomarker\u2013PRO relationships in cancer survivors and support comparative research across chronic disease populations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.72027","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T03:47:26Z","timestamp":1782791246000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sex\u2010, Age\u2010, Lifestyle\u2010, and Comorbidity\u2010Specific Reference Values for Serum Cytokines in the Dutch General Population: Results From the\n                    <scp>PROFILES<\/scp>\n                    Registry"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4476-2747","authenticated-orcid":false,"given":"Dounya","family":"Schoormans","sequence":"first","affiliation":[{"name":"CoRPS \u2010 Center of Research on Psychological Disorders and Somatic Diseases, 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