{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T11:04:51Z","timestamp":1784199891555,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5T32CA163177\u201012"],"award-info":[{"award-number":["5T32CA163177\u201012"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Health\u2010related quality of life (HRQOL) measures patients' overall well\u2010being and can help guide survivorship care. Evidence comparing individual patients' HRQOL pre\u2010 and post\u2010diagnosis is limited due to the unpredictable nature of cancer onset. Our study aims to evaluate trends in HRQOL in elderly colon cancer patients and identify predictors of HRQOL change across two key transitions: (1) pre\u2010 to post\u2010diagnosis, and (2) at diagnosis versus 2\u2009years later, with the goal of identifying at\u2010risk patients for a significant HRQOL decrease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Utilizing the SEER\u2010Medicare Health Outcomes Survey (SEER\u2010MHOS), patients diagnosed with colon cancer between 1998 and 2019, \u2265\u200965\u2009years old, and at least two HRQOL surveys were identified and grouped. Group 1 comprised patients with an initial survey pre\u2010diagnosis and a follow\u2010up survey within 1\u2009year from diagnosis, while Group 2 included patients with an initial survey within 1\u2009year from diagnosis and a follow\u2010up survey 2\u2009years later. Bayesian linear regression identified predictors of physical (PCS) and mental (MCS) score changes, incorporating demographic, socioeconomic, comorbidity, and cancer\u2010related variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The analysis included 1139 patients (Group 1: 571; Group 2: 568). PCS and MCS scores decreased substantially at diagnosis (4.4 and 2.2 points, respectively) compared to baseline but changed minimally from baseline (\u22120.3 and +0.6 points, respectively) 2\u2009years post\u2010diagnosis. Advanced disease stage and baseline ADL limitations were the strongest predictors of HRQOL decline, both from pre\u2010 to post\u2010diagnosis and from diagnosis to 2\u2009years later. Conversely, positive baseline health perception was protective (probability of direction &gt;\u200990% for all estimates).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Among colon cancer patients, patient\u2010reported baseline health perception and functional limitations emerged as critical determinants of HRQOL trajectories, outweighing socioeconomic and treatment\u2010related factors. These factors remain consistent upon diagnosis and during survivorship. Assessment of these factors could estimate HRQOL outcomes and facilitate early identification of at\u2010risk patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.72043","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T03:42:56Z","timestamp":1781754176000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Nationwide Analysis of Sociodemographic Disparities in Health\u2010Related Quality of Life of Colon Cancer Survivors"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-6962-9802","authenticated-orcid":false,"given":"Kaelyn C.","family":"Cummins","sequence":"first","affiliation":[{"name":"Department of Surgery University of Virginia  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad","family":"El Moheb","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Virginia  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan J.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Virginia  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengli","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Virginia  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4572-7038","authenticated-orcid":false,"given":"Victor","family":"Zaydfudim","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Virginia  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha M.","family":"Ruff","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Virginia  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan","family":"Tsung","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Virginia  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,17]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21731"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11764-007-0039-5"},{"key":"e_1_2_11_4_1","first-page":"241","volume-title":"Late Effects of Cancer and Its Treatment","author":"Ganz P. A.","year":"2001"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2015.09.006"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clcc.2015.07.003"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejon.2009.05.002"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477\u20107525\u20107\u2010102"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.33348"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136\u2010019\u201002280\u2010z"},{"issue":"4","key":"e_1_2_11_11_1","first-page":"5","article-title":"Overview of the SEER\u2014Medicare Health Outcomes Survey Linked Dataset","volume":"29","author":"Ambs A.","year":"2008","journal-title":"Health Care Financing Review"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2021.101901"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.1848"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2025.9147"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2007.82"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/hec.4730020305"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004479\u2010200610000\u201000007"},{"issue":"4","key":"e_1_2_11_18_1","first-page":"5","article-title":"Psychometric Evaluation of the SF\u201036 Health Survey in Medicare Managed Care","volume":"25","author":"Gandek B.","year":"2004","journal-title":"Health Care Financing Review"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199206000-00002"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11606\u2010015\u20103453\u20109"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2018.02.023"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1081\/COPD-200050663"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-8-330"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12029\u2010024\u201001070\u20102"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-006-9479-2"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2018.07.002"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055\u20109965.EPI\u201021\u20100555"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.7145"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549\u2010019\u201005356\u2010z"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12955\u2010018\u20100920\u20100"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.16339"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2019\u20100348"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/ecc.13601"},{"key":"e_1_2_11_34_1","first-page":"193","volume-title":"Psychological Health in Cancer Survivors","author":"Andrykowski M. A.","year":"2008"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21286"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(18)30093\u20107"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.72043","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cam4.72043","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.72043","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T10:04:31Z","timestamp":1784196271000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.72043"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":35,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/cam4.72043"],"URL":"https:\/\/doi.org\/10.1002\/cam4.72043","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"2025-09-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e72043"}}