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Liquid biopsy, a noninvasive approach analyzing tumor\u2010derived components in bodily fluids, has emerged as a promising tool in OC management. This review summarizes advances in liquid biopsy technologies, focusing on circulating tumor DNA (ctDNA) and circulating tumor cells (CTCs). ctDNA enables minimally invasive assessment for diagnosis, prognosis, treatment guidance (e.g., BRCA1\/2\u2010targeted therapy), minimal residual disease (MRD) detection, and monitoring of tumor evolution. CTCs, particularly clusters, provide insights into metastasis and therapeutic response. Emerging modalities such as tumor\u2010educated platelets (TEPs), circular RNAs (circRNAs), and exosomes and protease activity\u2010based liquid biopsy also show diagnostic and prognostic potential. Despite technical challenges like standardization and sensitivity, liquid biopsy holds significant promise for personalized OC care, with ongoing efforts to translate these technologies into clinical practice.<\/jats:p>","DOI":"10.1002\/cam4.72057","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T04:27:17Z","timestamp":1786336037000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Current Advances of Molecular Biomarkers and Liquid Biopsies Techniques in Ovarian Cancer"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8555-818X","authenticated-orcid":false,"given":"Jingxia","family":"Zhang","sequence":"first","affiliation":[{"name":"The Fourth Clinical Medical College of Zhejiang Chinese Medical University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiyan","family":"Shan","sequence":"additional","affiliation":[{"name":"The Fourth Clinical Medical College of Zhejiang Chinese Medical University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Yu","sequence":"additional","affiliation":[{"name":"The Fourth Clinical Medical College of Zhejiang Chinese Medical University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Shi","sequence":"additional","affiliation":[{"name":"The Fourth Clinical Medical College of Zhejiang Chinese Medical University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaoping","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Cancer Center, Affiliated Hangzhou First People's Hospital, Westlake University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6922-6718","authenticated-orcid":false,"given":"Hongkai","family":"Shang","sequence":"additional","affiliation":[{"name":"The Fourth Clinical Medical College of Zhejiang Chinese Medical University  Hangzhou China"},{"name":"Department of Gynecology Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University  Zhejiang Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,9]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21590"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.35278"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21871"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21559"},{"key":"e_1_2_15_6_1","unstructured":"R.Kurman M. 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