{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T10:09:37Z","timestamp":1784196577347,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100032579","name":"Beijing Medical Award Foundation","doi-asserted-by":"publisher","award":["YXJL\u20102020\u20100972\u20101216"],"award-info":[{"award-number":["YXJL\u20102020\u20100972\u20101216"]}],"id":[{"id":"10.13039\/100032579","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To develop and validate a simple intraoperative scoring system based on preoperative and cone\u2010beam CT (CBCT) features for real\u2010time prediction of objective response (OR) by mRECIST after DEB\u2010TACE in patients with HCC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      In this single\u2010center retrospective study, 274 patients (with a total of 386 HCC tumors) who underwent first\u2010session DEB\u2010TACE from 2022 to 2024 were included. CBCT was used to assess a 5\u2010grade marginal contrast saturation (MCS), capsule presence, vascular lake phenomenon (VLP), and other candidate imaging features. Tumor response was assessed on contrast\u2010enhanced CT using mRECIST. Analyses were performed on a tumor basis, with tumors assigned to development (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009286) and validation (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009100) sets by patient\u2010level stratified randomization (7:3). Variables associated with OR were entered into a multivariable logistic regression; \u03b2 coefficients were converted into a point\u2010based score. Model performance was evaluated in terms of discrimination and calibration using the AUROC and the Hosmer\u2013Lemeshow test.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Most patients were male (78.8%), with a mean age of 62.5\u2009\u00b1\u20099.4\u2009years. The median tumor diameter was 3.75\u2009cm (interquartile range [IQR], 2.50\u20136.50\u2009cm). The overall objective response rate (ORR) was 67.9% (262\/386). Multivariable analysis revealed four independent predictors of OR: tumor diameter, capsule presence, VLP, and MCS grade. A 1\u201310\u2010point score achieved excellent discrimination in the development set and maintained high performance in the validation set, with an AUROC of 0.93 (95% confidence interval [CI]: 0.86\u20130.99, goodness\u2010of\u2010fit\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.46).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>An imaging\u2010only, intraoperative scoring system incorporating tumor size, capsule, VLP, and MCS accurately predicts short\u2010term mRECIST response after DEB\u2010TACE, facilitating rapid decision\u2010making and subsequent patient management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.72062","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T04:43:08Z","timestamp":1782189788000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Marginal Contrast Saturation\u2010Based Intraoperative Scoring System Predicts Objective Response to\n                    <scp>DEB<\/scp>\n                    \u2010\n                    <scp>TACE<\/scp>\n                    : Development and Validation of a\n                    <scp>CBCT<\/scp>\n                    \u2010Derived Real\u2010Time Score"],"prefix":"10.1002","volume":"15","author":[{"given":"Zhongsong","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Interventional Radiology Central Hospital, Tianjin University\/Tianjin Third Central Hospital  Tianjin 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