{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T03:29:36Z","timestamp":1786418976156,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This registry\u2010based study investigates patients with resected esophageal (EAC), cardiac (CAC), and gastric (GAC) pT1 adenocarcinoma (AC) concerning epidemiological, tumor\u2010related, and prognostic factors, analyzing especially the impact on survival and years of life lost (YLL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>As CAC is classified as esophageal cancer in the 7th and more specified in the 8th edition of the UICC\u2010TNM classification, it remains unclear if significant differences exist for pT1 CAC in comparison to EAC and GAC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We used the ICD\u2010O\u20103 code comparing tumors in the esophagus (C15.0\u2010C15.9), cardia (C16.0), and stomach (C16.1\u2010C16.9). A total of 246,653 patients with these tumors were documented between 2010\u20132020 in the German Cancer Registry. Only ACs with histologically confirmed tumor infiltration into mucosa or submucosa (pT1) were included. YLL were calculated using life expectancy data from Germany.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study population consists of 9.442 patients with resected pT1 AC. Age and sex differed significantly between CAC (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091.870) and EAC (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20092.018) as well as between CAC and GAC (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20095.554). Tumor\u2010related factors were significantly different between the three locations. Multivariate analysis showed significantly worse prognosis for CAC compared to the other locations. The median of YLL was 10.7\u2009years for EAC, 8.5\u2009years for CAC and 6.8\u2009years for GAC (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Patients with pT1 AC of the cardia differ from patients with EAC or GAC in terms of demographic, tumor\u2010related factors, prognosis, and YLL. Therefore, separate classification of tumors originating in the cardia is useful. Future studies should investigate the influence of therapy on prognosis and YLL.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.72079","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T03:59:19Z","timestamp":1782964759000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Years of Life Lost of Patients With Early Adenocarcinoma of the Esophagogastric Junction Compared to Esophageal or Gastric Adenocarcinoma. A Registry\u2010Based Study"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2442-8397","authenticated-orcid":false,"given":"Elfriede","family":"Bollschweiler","sequence":"first","affiliation":[{"name":"Medical Faculty University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnulf H.","family":"H\u00f6lscher","sequence":"additional","affiliation":[{"name":"Center for Esophageal Diseases Elisabeth\u2010Krankenhaus Essen  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Schumacher","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Gastroenterologie, Hepatologie und Transplantationsmedizin Universit\u00e4tsmedizin Essen  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Pech","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Gastroenterologie und Interventionelle Endoskopie Krankenhaus Barmherzige Br\u00fcder Regensburg  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uta","family":"Drebber","sequence":"additional","affiliation":[{"name":"Institute of Pathology University of Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"in Cooperation with the German Cancer Registry, RKI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,1]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2017.155"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-024-13151-3"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/0284186X.2022.2163592"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20010801)92:3<549::AID-CNCR1354>3.0.CO;2-L"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-023-08126-6"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/dote\/doaf018"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1673-1118"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(25)00052-2"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.4251\/wjgo.v17.i4.103455"},{"key":"e_1_2_12_12_1","first-page":"25","article-title":"Kardiakarzinom. 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