{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T05:45:41Z","timestamp":1791870341465,"version":"4.3.4"},"reference-count":25,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing Municipality","doi-asserted-by":"publisher","award":["CSTB2024NSCQ\u2010KJFZZDX0021"],"award-info":[{"award-number":["CSTB2024NSCQ\u2010KJFZZDX0021"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Venetoclax (VEN)\u2010based regimens improve remission in acute myeloid leukemia (AML), but infectious toxicity remains a concern. We compared infection profiles under VEN\u2010based versus conventional therapy in newly diagnosed, non\u2010M3 AML at a single tertiary center (2015\u20132024;\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009358; VEN\u2009=\u2009156; non\u2010VEN\u2009=\u2009202). After 1:1 propensity\u2010score matching on nine baseline covariates (115 per group), we assessed infection rates and event density (events per 1000 person\u2010days) by site and pathogen, time to first infection (120\u2010day cumulative incidence), and landmark associations between early infections and progression\u2010free survival (PFS). Baseline predictors of microbiologically documented infection (MDI) were modeled in the pre\u2010matching cohort. VEN was associated with higher febrile\u2010neutropenia (FN) event density (IRR, 1.77; 95% CI, 1.33\u20132.36;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001; 16.40 vs. 9.27 per 1000 person\u2010days). Site\u2010level patterns diverged: upper\u2010respiratory and lung infections showed lower first\u2010event incidence with VEN, whereas skin\/soft\u2010tissue and perianal sites showed higher event density without higher patient\u2010level incidence. By pathogen, bacterial and fungal first events were fewer with VEN while event densities were comparable; viral infections occurred earlier and accrued higher cumulative incidence. Cumulatively, the first infection was lower with VEN at days 30, 60, and 90 but converged by day 120. In the pre\u2010matching cohort, higher HCT\u2010CI (1\u20132\/\u2265\u20093 vs. 0) and higher DBIL independently predicted MDI, while female sex predicted lower risk. MDIs within 90\u2009days\u2014bacterial\/fungal\u2010driven\u2014were associated with inferior PFS at 100 and 365\u2009days, whereas early viral infections showed no association.\n                  <\/jats:p>","DOI":"10.1002\/cam4.72087","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T05:03:33Z","timestamp":1791867813000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Infection Profiles Under Venetoclax\u2010Based Therapy in Newly Diagnosed Acute Myeloid Leukemia: A Real\u2010World Study"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-3555-7386","authenticated-orcid":false,"given":"Guilin","family":"Ren","sequence":"first","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Chongqing Medical University  Chongqing 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianbin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqiong","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Chongqing Medical University  Chongqing 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,12]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2024024009"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2012971"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26039"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26991"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beha.2021.101335"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/16078454.2024.2343604"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2018.01.029"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.14283"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2023020102"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13246285"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2023011964"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375\u2010022\u201001556\u20107"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.27246"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.1012334"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofac486"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520\u2010022\u201007126\u2010y"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2019000930"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.18051"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102005\u201005\u20102004"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23443"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102016\u201008\u2010733196"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1158\/2326\u20106066.CIR\u201023\u20100344"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11739\u2010011\u20100517\u20107"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020009081"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375\u2010022\u201001786\u20109"}],"container-title":["Cancer 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