{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T01:01:51Z","timestamp":1788915711138,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Adolescent and young adult (AYA) patients with acute lymphoblastic leukemia (ALL) are a growing population with unfavorable outcomes relative to pediatric peers. Historic underrepresentation in prospective studies has complicated unifying recommendations surrounding optimal therapeutic strategy for this group. Retrospective studies highlighting the superiority of pediatric\u2010inspired regimens in this context have given rise to small prospective trials supporting these findings. Data demonstrating concordant implementation of these protocols outside of clinical trials is lacking. We designed a retrospective study summarizing therapeutic strategies for over 200 AYAs with ALL treated within an integrated healthcare system. We found increasing usage of pediatric protocols over the study period associated with higher utilization of outpatient clinic appointments, lower number of inpatient days, equivalent toxicity profiles, and favorable mortality rates. Our findings highlight the wide implementation and superiority of pediatric regimens for AYAs undergoing treatment for ALL in the community setting, for which more data have been needed.<\/jats:p>","DOI":"10.1002\/cam4.72094","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T06:42:21Z","timestamp":1783665741000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Community Experience With Pediatric\u2010Inspired Regimens for Acute Lymphoblastic Leukemia in Adolescent and Young Adults"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2091-8869","authenticated-orcid":false,"given":"Matthew T.","family":"Newman","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Kaiser Permanente Los Angeles Medical Center  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah S.","family":"Gho","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology University of California San Francisco Benioff Children's Hospital Oakland  Oakland California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela M.","family":"Hull","sequence":"additional","affiliation":[{"name":"Department of Research &amp; Evaluation Kaiser Permanente Southern California  Pasadena California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faisal N.","family":"Cheema","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Kaiser Permanente Santa Clara Medical Center  Santa Clara California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8936-6596","authenticated-orcid":false,"given":"Robert M.","family":"Cooper","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology Kaiser Permanente Los Angeles Medical Center  Los Angeles California USA"},{"name":"Department of Health Systems Science Kaiser Permanente Bernard J. Tyson School of Medicine  Pasadena California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21637"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102014\u201011\u2010551481"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102018\u201002\u2010778530"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/curroncol30090625"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2349"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29871"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/jayao.2010.0001"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.27617"},{"key":"e_1_2_11_9_2","unstructured":"[Published correction appears inCancer120 no.14(2014):2222]."},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28930"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2017.5305"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102018\u201010\u2010881961"},{"key":"e_1_2_11_12_2","doi-asserted-by":"crossref","unstructured":"[Published correction appears inBlood134 no.13(2019):1111 https:\/\/doi.org\/10.1182\/blood.2019002613].","DOI":"10.1182\/blood.2019002613"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.0253\u20102727.2020.05.007"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2021005576"},{"key":"e_1_2_11_14_2","doi-asserted-by":"crossref","unstructured":"Erratum in:Blood Advances7 no.16(2023):4620 https:\/\/doi.org\/10.1182\/bloodadvances.2023010637.","DOI":"10.1182\/bloodadvances.2023010637"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26066"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375\u2010021\u201001460\u20106"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.2096"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102407\u201014\u2010805"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.27523"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30322"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2017014944"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.324.7330.135"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.37765\/ajmc.2021.88631"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2021.09.036"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.56.8642"},{"key":"e_1_2_11_26_1","volume-title":"Delivering High\u2010Quality Cancer Care: Charting a New Course for a System in Crisis","author":"Institute of Medicine","year":"2013"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.72094","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cam4.72094","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.72094","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T02:52:19Z","timestamp":1786416739000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.72094"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":28,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/cam4.72094"],"URL":"https:\/\/doi.org\/10.1002\/cam4.72094","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2025-06-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e72094"}}