{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T03:29:06Z","timestamp":1786418946476,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This real\u2010world study aimed to investigate the cancer therapy\u2010induced thrombocytopenia (CTIT) profile and evaluate the efficacy and safety of recombinant human interleukin\u201011 (rhIL\u201011) in its management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective analysis included 12,431 CTIT patients treated with rhIL\u201011 across 58 Chinese centers (July 2023\u2013June 2024). Multivariate logistic regression analysis identified CTIT risk factors. Treatment outcomes and adverse events (AEs) were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Independent CTIT risk factors included advanced age, medical history, prior myelosuppression, tumor type, bone marrow involvement, and previous anti\u2010tumor therapy. RhIL\u201011 demonstrated significant thrombopoietic effects, with a mean treatment duration of 6.79\u2009\u00b1\u20092.59\u2009days. Platelet (PLT) recovery to 50\u2009\u00d7\u200910\n                      <jats:sup>9<\/jats:sup>\n                      \/L and 100\u2009\u00d7\u200910\n                      <jats:sup>9<\/jats:sup>\n                      \/L was 4.60\u2009\u00b1\u20094.40\u2009days and 7.68\u2009\u00b1\u20095.09\u2009days, respectively. Hematologic malignancy patients required longer treatment and slower PLT recovery compared to those with solid tumors. Urologic and head\/neck malignancy patients had faster recovery, while uterine, colorectal, and liver cancer patients exhibited poorer outcomes. Fluoropyrimidine monotherapy delayed PLT recovery compared to platinum\u2010, taxane\u2010, anthracycline\u2010based regimens, or gemcitabine\/platinum combinations (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Furthermore, patients with \u201cimpaired\u201d PLT recovery capacity or grade IV CTIT demonstrated longer treatment and PLT recovery times, while grade I\/III CTIT was associated with higher PLT recovery response rates. AEs occurred in 28.9% of patients, primarily mild fatigue (15.3%) and edema (7.5%). COVID\u201019 infection correlated with prolonged treatment duration and delayed PLT normalization.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This large\u2010scale real\u2010world study confirms the efficacy and safety of rhIL\u201011 in CTIT management. Treatment responses vary slightly across patient subgroups, but tolerability remains acceptable. Findings emphasize individualized CTIT strategies and proactive AEs monitoring.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.72101","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T03:56:16Z","timestamp":1783655776000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and Safety of\n                    <scp>rhIL<\/scp>\n                    \u201011 in the Treatment of Cancer Therapy\u2010Induced Thrombocytopenia: A Multicenter Retrospective Study"],"prefix":"10.1002","volume":"15","author":[{"given":"Yingmei","family":"Wen","sequence":"first","affiliation":[{"name":"Cancer Center Renmin Hospital of Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Dong","sequence":"additional","affiliation":[{"name":"Cancer Center Renmin Hospital of Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingge","family":"Li","sequence":"additional","affiliation":[{"name":"Cancer Center Renmin Hospital of Wuhan University  Wuhan China"},{"name":"Hubei Provincial Research Center for Precision Medicine of Cancer  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinxiong","family":"Xia","sequence":"additional","affiliation":[{"name":"Cancer Center Renmin Hospital of Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheming","family":"Liu","sequence":"additional","affiliation":[{"name":"Cancer Center Renmin Hospital of Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Cancer Center Renmin Hospital of Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruibin","family":"Li","sequence":"additional","affiliation":[{"name":"Cancer Center Renmin Hospital of Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2836-1217","authenticated-orcid":false,"given":"Ming","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Renmin Hospital of Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0499-0430","authenticated-orcid":false,"given":"Bin","family":"Xu","sequence":"additional","affiliation":[{"name":"Cancer Center Renmin Hospital of Wuhan University  Wuhan China"},{"name":"Hubei Provincial Research Center for Precision Medicine of Cancer  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9656-0357","authenticated-orcid":false,"given":"Dongling","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Renmin Hospital of Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lulu","family":"Chen","sequence":"additional","affiliation":[{"name":"Cancer Center Renmin Hospital of Wuhan University  Wuhan China"},{"name":"Hubei Provincial Research Center for Precision Medicine of Cancer  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7312-6841","authenticated-orcid":false,"given":"Huibo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Cancer Center Renmin Hospital of Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4350-0916","authenticated-orcid":false,"given":"Qibin","family":"Song","sequence":"additional","affiliation":[{"name":"Cancer Center Renmin Hospital of Wuhan University  Wuhan China"},{"name":"Hubei Provincial Research Center for Precision Medicine of Cancer  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3110-1720","authenticated-orcid":false,"given":"Yi","family":"Yao","sequence":"additional","affiliation":[{"name":"Cancer Center Renmin Hospital of Wuhan University  Wuhan China"},{"name":"Hubei Provincial Research Center for Precision Medicine of Cancer  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2021.279512"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.20037"},{"key":"e_1_2_11_4_1","volume-title":"Guidelines of Chinese Society of Clinical Oncology (CSCO) Cancer Therapy Induced Thrombocytopenia","author":"Guideline Working Committee of Chinese Society of Clinical Oncology","year":"2025"},{"key":"e_1_2_11_5_1","unstructured":"National Cancer Institute \u201cCommon Terminology Criteria for Adverse Events (CTCAE). 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