{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T13:19:11Z","timestamp":1787663951133,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The standard treatment regimen for limited\u2010stage small cell lung cancer (LS\u2010SCLC) is 4\u20136\u2009cycles of chemotherapy combined with thoracic radiotherapy. However, most patients still experience disease recurrence in a short period. Therefore, this study aims to evaluate the associations of different chemotherapy and radiotherapy strategies with survival outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective analysis included LS\u2010SCLC patients treated with chemotherapy and accelerated hyperfractionated radiotherapy. Progression\u2010free survival (PFS) served as the primary endpoint, while overall survival (OS) and brain metastasis\u2010free survival (BMFS) were evaluated as secondary endpoints.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 201 eligible patients were included. No significant survival difference was observed between patients receiving 4\u2009cycles and those receiving 5\u20136\u2009cycles of chemotherapy (HR: 0.83, 95% CI: 0.58\u20131.21,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.332). Patients who received more than 45 Gy did not gain more survival benefit compared to those who received the standard 45 Gy dose, with median PFS of 13.1 and 13.9\u2009months, respectively (HR: 1.43, 95% CI: 0.90\u20132.26,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.125). This study found that radiotherapy interval &gt;\u200975\u2009days was associated with improved PFS compared with an interval \u2264\u200975\u2009days (HR: 0.71, 95% CI: 0.48\u20130.97,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.044).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>For LS\u2010SCLC patients receiving accelerated hyperfractionated radiotherapy, higher total doses did not provide significant benefits compared to the standard dose (45 Gy\/30 F). Although a radiotherapy interval &gt;\u200975\u2009days was associated with improved PFS and OS, this finding should be interpreted cautiously and requires prospective validation before being used to guide radiotherapy timing. Regarding chemotherapy, patients receiving 5\u20136\u2009cycles of chemotherapy did not show significant benefits compared to those receiving 4\u2009cycles.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.72126","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T07:37:19Z","timestamp":1786001839000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chemotherapy and Radiotherapy Regimens for Limited\u2010Stage Small Cell Lung Cancer Treated With Accelerated Hyperfractionated Radiotherapy Combined With Chemotherapy: A Real\u2010World Study"],"prefix":"10.1002","volume":"15","author":[{"given":"Junfeng","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences  Jinan Shandong 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5691-2780","authenticated-orcid":false,"given":"Chengxin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences  Jinan Shandong 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