{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T03:29:21Z","timestamp":1786418961782,"version":"build-2736575974"},"reference-count":52,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["U01CA206110"],"award-info":[{"award-number":["U01CA206110"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000056","name":"National Institute of Nursing Research","doi-asserted-by":"publisher","award":["R01NR018762"],"award-info":[{"award-number":["R01NR018762"]}],"id":[{"id":"10.13039\/100000056","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Fatigue affects up to 90% of patients with cancer during chemotherapy and persists in approximately 30% after treatment completion. This study examined the longitudinal associations between fatigue and 16 inflammatory markers in patients with colorectal cancer (CRC) up to 3\u2009years after surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with Stage I\u2013IV CRC who participated in the prospective ColoCare cohort study were included. Fatigue was measured using the 3\u2010item fatigue subscale of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC\u2010QLQ\u2010C30) at baseline and each subsequent time point (score range: 0\u2013100). Inflammatory markers were measured using blood specimens from each time point (T0: baseline\/surgery; T1: 3\u20139\u2009months; T2: 10\u201319\u2009months; T3: 20\u201336\u2009months post\u2010baseline). Linear mixed\u2010effects models were used to examine associations between inflammatory markers and fatigue scores over time. Linear regression was used to analyze the relationships between T0\/T1 markers and fatigue at T3.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There were 271 patients with Stage I\u2013III CRC and 30 patients with Stage IV CRC. Among patients with Stage I\u2013III CRC, mean fatigue peaked at T1 (36.9), with higher fatigue among women than men (44.8 vs. 30.9). In longitudinal mixed\u2010effects models, twofold higher mean levels of IL\u20106 and IL\u201017A were associated with higher fatigue over time (3.51 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01) and 3.91 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01), respectively). IL\u20104, IL\u201017A, and TNF\u2010\u03b1 at T1 were nominally associated with higher levels of fatigue at T3.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Higher levels of selected inflammatory biomarkers were associated with fatigue up to 3\u2009years after CRC diagnosis. These markers may help identify patients at risk for persistent fatigue and warrant further study as potential therapeutic targets.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.72135","type":"journal-article","created":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T03:53:31Z","timestamp":1784951611000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Longitudinal Associations Between Inflammatory Biomarkers and Fatigue in Patients With Colorectal Cancer: A Multicenter Study"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8302-3157","authenticated-orcid":false,"given":"Nicole C.","family":"Loro\u00f1a","sequence":"first","affiliation":[{"name":"Samuel Oschin Comprehensive Cancer Institute Cedars\u2010Sinai Cancer  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louisa","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Medicine Cedars\u2010Sinai Medical Center  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elham","family":"Kazemian","sequence":"additional","affiliation":[{"name":"Samuel Oschin Comprehensive Cancer Institute Cedars\u2010Sinai Cancer  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Acuna","sequence":"additional","affiliation":[{"name":"Samuel Oschin Comprehensive Cancer Institute Cedars\u2010Sinai Cancer  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary C.","family":"Playdon","sequence":"additional","affiliation":[{"name":"Huntsman Cancer Institute, University of Utah  Salt Lake City Utah USA"},{"name":"Department of Population Health Sciences University of Utah  Salt Lake City Utah USA"},{"name":"Department of Nutrition and Integrative Physiology, College of Health University of Utah  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher L.","family":"Cubitt","sequence":"additional","affiliation":[{"name":"Immune Monitoring Core H. 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