{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T13:19:03Z","timestamp":1787663943724,"version":"build-2736575974"},"reference-count":20,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100010256","name":"Guangzhou Municipal Science and Technology Project","doi-asserted-by":"publisher","award":["No. 2024A04J4703"],"award-info":[{"award-number":["No. 2024A04J4703"]}],"id":[{"id":"10.13039\/501100010256","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 2022GZRPYQN10"],"award-info":[{"award-number":["No. 2022GZRPYQN10"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Patients with acute myeloid leukemia (AML) experience severe infections frequently during and after chemotherapy. The purpose of this study was to develop an early risk assessment tool to identify newly diagnosed AML patients at high risk of developing sepsis during the early phase of induction chemotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The records of 192 newly diagnosed AML patients from February 2017 to December 2023 at our institution were retrospectively reviewed. Kaplan\u2013Meier survival analysis was performed to explore the prognosis difference between groups with or without sepsis. Mann\u2013Whitney\n                      <jats:italic>U<\/jats:italic>\n                      test, Chi\u2010square test, and multivariable logistic regression analysis were used to identify independent risk factors and establish a nomogram for early risk stratification of sepsis. The predictive accuracy of the nomogram was evaluated using the area under the curve (AUC), calibration curves, and concordance index (C\u2010index). The nomogram is intended for application on days 3\u20135 of induction chemotherapy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Multivariate logistic regression identified TP53 mutation, elevated aspartate aminotransferase (AST) and C\u2010reactive protein (CRP) at diagnosis, increased procalcitonin (PCT), and higher urea levels post\u2010induction as independent risk factors for sepsis progression. The bootstrap\u2010corrected AUC was 0.892 (C\u2010index 0.892). The bias\u2010corrected calibration curve was close to the ideal line, demonstrating strong consistency between actual observations and predictions. Patients with sepsis experienced a poorer prognosis (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) both at 1\u2010year and 5\u2010year survival rates. The incidence rates of pneumonia and invasive fungal infection were higher in the sepsis group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We developed a nomogram for early identification of sepsis risk in newly diagnosed AML patients during their initial induction chemotherapy. This tool may assist clinicians in identifying patients requiring close monitoring and intensive supportive care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.72138","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T10:56:38Z","timestamp":1785149798000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Early Risk Identification of Sepsis During Induction Chemotherapy in Newly Diagnosed\n                    <scp>AML<\/scp>\n                    : A Nomogram\u2010Based Tool"],"prefix":"10.1002","volume":"15","author":[{"given":"Cui\u2010Ying","family":"Gu","sequence":"first","affiliation":[{"name":"Department of Hematology The Third Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya\u2010Shu","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Hematology The Third Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing\u2010Song","family":"He","sequence":"additional","affiliation":[{"name":"Department of Hematology The Third Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology The Third Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5991-7388","authenticated-orcid":false,"given":"Jia\u2010Jun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hematology The Third Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou 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