{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T13:19:08Z","timestamp":1787663948958,"version":"build-2736575974"},"reference-count":19,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["320030\u2010163342\/1"],"award-info":[{"award-number":["320030\u2010163342\/1"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004361","name":"Krebsliga Schweiz","doi-asserted-by":"publisher","award":["KFS\u20103932\u201008\u20102016\u2010R"],"award-info":[{"award-number":["KFS\u20103932\u201008\u20102016\u2010R"]}],"id":[{"id":"10.13039\/501100004361","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004361","name":"Krebsliga Schweiz","doi-asserted-by":"publisher","award":["KFS\u20105243\u201002\u20102021"],"award-info":[{"award-number":["KFS\u20105243\u201002\u20102021"]}],"id":[{"id":"10.13039\/501100004361","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003360","name":"Ligue Genevoise Contre le Cancer","doi-asserted-by":"publisher","award":["subvention 1813"],"award-info":[{"award-number":["subvention 1813"]}],"id":[{"id":"10.13039\/501100003360","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Disparities in survival between left\u2010 versus right\u2010sided colon cancer have been reported. We studied the role of sidedness on survival of colon cancer across tumor biomarkers subgroups in a population\u2010based cohort established using the Geneva Cancer Registry database. Our study included 3503 colon cancer cases diagnosed between 1985 and 2013. Right\u2010sided colon cancers (ICD\u2010O codes C18.0, C18.2\u201318.4) and left\u2010sided colon cancers (ICD\u2010O codes C18.5\u201318.7) were compared. Five\u2010year net survival was estimated using the Pohar\u2010Perme estimator. Flexible hazard models evaluated the association of survival with sidedness adjusted for patient, tumor, and treatment characteristics. Left\u2010sided colon cancers were more frequent than right\u2010sided colon cancers (53% vs. 47%). Right\u2010sided colon cancer cases were older and more often women, less frequently of stage I or well differentiated. Left\u2010sided colon cancer had a higher 5\u2010year net survival than right\u2010sided colon cancer (66% vs. 59%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). In a multivariable model, patients with a left\u2010sided tumor had a 25% reduction in 5\u2010year mortality compared with right\u2010sided tumors (excess hazard ratio [eHR]: 0.75, 95% confidence interval [CI]: 0.63\u20130.89,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.001). This association remained significant only among stage IV while not among stages I\u2010III. Among a subgroup of 2438 cases, stratification on tumor molecular biomarkers confirmed the better prognosis of left\u2010sided colon cancer versus right\u2010sided colon cancer among microsatellite stable (MSS) tumors, tumors with BRAF wild\u2010type (BRAFwt), and iCMS2 tumors. This study shows the importance of sidedness for prognosis and treatment considerations in addition to tumor biomarkers. Further research is needed to assess the molecular mechanisms underlying these differences between left and right colon cancer to address the prognostic gap.\n                  <\/jats:p>","DOI":"10.1002\/cam4.72140","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T01:24:54Z","timestamp":1787189094000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Survival of Colon Cancer in a Population\u2010Based Cohort Study: A Comprehensive Analysis of Location of the Primary Tumor"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3594-0732","authenticated-orcid":false,"given":"Pauline","family":"Brindel","sequence":"first","affiliation":[{"name":"Geneva Cancer Registry Institute of Global Health, University of Geneva  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6717-8020","authenticated-orcid":false,"given":"Evelyne","family":"Fournier","sequence":"additional","affiliation":[{"name":"Geneva Cancer Registry Institute of Global Health, University of Geneva  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3464-9241","authenticated-orcid":false,"given":"Pierre Olivier","family":"Chappuis","sequence":"additional","affiliation":[{"name":"Oncogenetics Unit, Division of Precision Oncology Geneva University Hospitals  Geneva Switzerland"},{"name":"Division of Genetic Medicine Geneva University Hospitals  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2147-3136","authenticated-orcid":false,"given":"Thomas","family":"McKee","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology Geneva University Hospitals  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Kreutzfeldt","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology University of Geneva  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Puppa","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology Geneva University Hospitals  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology Geneva University Hospitals  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3730-5348","authenticated-orcid":false,"given":"Jakob Nikolas","family":"Kather","sequence":"additional","affiliation":[{"name":"Else Kroener Fresenius Center for Digital Health Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology  Dresden Germany"},{"name":"Department of Medicine I Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology  Dresden Germany"},{"name":"Medical Oncology, National Center for Tumor Diseases (NCT) University Hospital Heidelberg  Heidelberg Germany"},{"name":"Pathology &amp; Data Analytics Leeds Institute of Medical Research at St James's, University of Leeds  Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7847-7728","authenticated-orcid":false,"given":"Elisabetta","family":"Rapiti","sequence":"additional","affiliation":[{"name":"Geneva Cancer Registry Institute of Global Health, University of Geneva  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Benhamou","sequence":"additional","affiliation":[{"name":"INSERM Unit 1018 Research Center on Epidemiology and Population Health  Villejuif \u00cele de France France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,19]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(19)32319\u20100"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588\u2010022\u201001100\u20104"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2022.10.003"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010020\u20100116\u2010z"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2016.4227"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434\u2010019\u201007164\u20107"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2016.04.002"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055\u20109965.EPI\u201021\u20100555"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/oncolo\/oyad074"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102022\u2010063914"},{"key":"e_1_2_13_12_1","volume-title":"International Classification of Diseases for Oncology","author":"Fritz A.","year":"2013"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885\u2010016\u20102967\u20109"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1037\/1082\u2010989X.7.2.147"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/09622802211031615"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.36666"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535\u2010023\u201001955\u20102"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djt173"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2016.126"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.02.029"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.72140","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cam4.72140","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.72140","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T12:25:09Z","timestamp":1787660709000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.72140"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":19,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/cam4.72140"],"URL":"https:\/\/doi.org\/10.1002\/cam4.72140","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"2025-04-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e72140"}}