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In this post hoc exploratory study, we analyzed fatigue and other secondary outcomes from a randomized trial aimed at exploring if prehabilitation by additional physical activity could improve postoperative recovery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>PHYSSURG C was a multicenter, controlled, randomized trial. Patients diagnosed with colorectal cancer were randomized to additional unsupervised moderate physical exercise in accordance with WHO guidelines or usual care two weeks before and four weeks after surgery. Trial\u2010specific questionnaires were used at baseline, at 4\u2009weeks and 12\u2009months. Outcomes were self\u2010reported fatigue as well as quality of life, pain, and mental recovery at both postoperative follow\u2010up times.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 518 patients were included in this analysis. At 4\u2009weeks after surgery, the mean difference in fatigue was 3.75 ((CI 0.01;7.49),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.05) with intention to treat approach, and in a per protocol analysis at 4\u2009weeks the mean difference was 4.04 ((CI 0.14;7.93),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04), and at 12\u2009months it was 4.29 ((CI 0.44; 8.14),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03). There were no differences between the intervention and control groups regarding quality of life, pain, or mental recovery.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This exploratory study found a suggestion of less postoperative fatigue in the intervention group. Further studies are needed to define the role of unsupervised moderate exercise, if any, before and after surgery in regard to postoperative fatigue in patients with colorectal cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      identifier: NCT02299596\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.72142","type":"journal-article","created":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T07:11:23Z","timestamp":1786173083000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effects of Prehabilitation by Physical Activity on Fatigue After Surgery for Colorectal Cancer. Results From Secondary Analyses in the Randomized Controlled Trial\n                    <scp>PHYSSURG<\/scp>\n                    \u2010C"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6663-5242","authenticated-orcid":false,"given":"Kevin","family":"Afshari","sequence":"first","affiliation":[{"name":"Scandinavian Surgical Outcomes Research Group (SSORG), Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"},{"name":"Department of Surgery Sahlgrenska University Hospital  Gothenburg Region Vastra G\u00f6taland Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1946-3529","authenticated-orcid":false,"given":"Aron","family":"Onerup","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"},{"name":"Department of Pediatric Oncology Sahlgrenska University Hospital  Gothenburg Region Vastra G\u00f6taland Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7108-6532","authenticated-orcid":false,"given":"Ying","family":"Li","sequence":"additional","affiliation":[{"name":"Scandinavian Surgical Outcomes Research Group (SSORG), Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9966-4904","authenticated-orcid":false,"given":"Eva","family":"Angenete","sequence":"additional","affiliation":[{"name":"Scandinavian Surgical Outcomes Research Group (SSORG), Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"},{"name":"Department of Surgery Sahlgrenska University Hospital  Gothenburg Region Vastra G\u00f6taland 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