{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T13:18:56Z","timestamp":1787663936760,"version":"build-2736575974"},"reference-count":20,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T00:00:00Z","timestamp":1785024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T00:00:00Z","timestamp":1785024000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82400201"],"award-info":[{"award-number":["82400201"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82470186"],"award-info":[{"award-number":["82470186"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20241117"],"award-info":[{"award-number":["BK20241117"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20232039"],"award-info":[{"award-number":["BK20232039"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2025M772095"],"award-info":[{"award-number":["2025M772095"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The incidence of primary central nervous system low\u2010grade B\u2010cell lymphoma (PCNSL\u2010LG) is rare. We aimed to provide the first large\u2010scale analysis of treatment modalities, survival trends, and prognostic factors for PCNSL\u2010LG. Patient data diagnosed between 2000 and 2021 were extracted from the Surveillance, Epidemiology, and End Results (SEER) database. A total of 267 adult PCNSL\u2010LG patients were included. The year of diagnosis was divided into the time period\u20101 (2000\u20132009) and the time period\u20102 (2010\u20132021). Radiotherapy alone usage remained stable over time (27.34% vs. 30.22%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.605). Chemotherapy alone showed a modest, non\u2010significant increase (25.00% vs. 31.66%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.229), while combined chemoradiotherapy declined significantly from 29.69% to 15.11% (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.004). The 1\u2010, 5\u2010, and 10\u2010year overall survival (OS) rates for all PCNSL\u2010LG patients were 84.3%, 73.4%, and 61.8%, respectively. Overall survival improved significantly, with median OS extending from 11.25\u2009years in period\u20101 to not reached in period\u20102 (HR 0.46, 95% CI: 0.28\u20130.74;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.001). Surgery was associated with improved outcomes compared with non\u2010surgical management (HR 0.47, 95% CI: 0.31\u20130.72,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). In patients with MALT lymphoma histology, no significant prognostic difference was observed across treatment modalities (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.838). This study underscores a marked improvement in survival among PCNSL\u2010LG patients over the past two decades and offers valuable insights for optimizing clinical management and improving patient outcomes.\n                  <\/jats:p>","DOI":"10.1002\/cam4.72147","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T05:41:31Z","timestamp":1785130891000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Survival Outcomes and Prognostic Factors in Patients With Primary Central Nervous System Low\u2010Grade B\u2010Cell Lymphoma: A Population\u2010Based Cohort Study"],"prefix":"10.1002","volume":"15","author":[{"given":"Lvwen","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Hematology Jiangsu Province Engineering Research Center of Cell and Gene Therapy for Hematologic and Lymphoid Diseases, The First Affiliated Hospital with Nanjing Medical University, Jiangsu Province Hospital  Nanjing China"},{"name":"Department of Hematology The People's Hospital of Jiangyin, Affiliated Jiangyin Hospital of Nantong University  Jiangyin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Hematology Jiangsu Province Engineering Research Center of Cell and Gene Therapy for Hematologic and Lymphoid Diseases, The First Affiliated Hospital with Nanjing Medical University, Jiangsu Province Hospital  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxiao","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Hematology Jiangsu Province Engineering Research Center of Cell and Gene Therapy for Hematologic and Lymphoid Diseases, The First Affiliated Hospital with Nanjing Medical University, Jiangsu Province Hospital  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hematology Jiangsu Province Engineering Research Center of Cell and Gene Therapy for Hematologic and Lymphoid Diseases, The First Affiliated Hospital with Nanjing Medical University, Jiangsu Province Hospital  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanmei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology Jiangsu Province Engineering Research Center of Cell and Gene Therapy for Hematologic and Lymphoid Diseases, The First Affiliated Hospital with Nanjing Medical University, Jiangsu Province Hospital  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Hematology Jiangsu Province Engineering Research Center of Cell and Gene Therapy for Hematologic and Lymphoid Diseases, The First Affiliated Hospital with Nanjing Medical University, Jiangsu Province Hospital  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiran","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology Jiangsu Province Engineering Research Center of Cell and Gene Therapy for Hematologic and Lymphoid Diseases, The First Affiliated Hospital with Nanjing Medical University, Jiangsu Province Hospital  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5302-9873","authenticated-orcid":false,"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology Jiangsu Province Engineering Research Center of Cell and Gene Therapy for Hematologic and Lymphoid Diseases, The First Affiliated Hospital with Nanjing Medical University, Jiangsu Province Hospital  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Qu","sequence":"additional","affiliation":[{"name":"Department of Hematology Jiangsu Province Engineering Research Center of Cell and Gene Therapy for Hematologic and Lymphoid Diseases, The First Affiliated Hospital with Nanjing Medical University, Jiangsu Province Hospital  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengxu","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Hematology Jiangsu Province Engineering Research Center of Cell and Gene Therapy for Hematologic and Lymphoid Diseases, The First Affiliated Hospital with Nanjing Medical University, Jiangsu Province Hospital  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Hematology Jiangsu Province Engineering Research Center of Cell and Gene Therapy for Hematologic and Lymphoid Diseases, The First Affiliated Hospital with Nanjing Medical University, Jiangsu Province Hospital  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematology Jiangsu Province Engineering Research Center of Cell and Gene Therapy for Hematologic and Lymphoid Diseases, The First Affiliated Hospital with Nanjing Medical University, Jiangsu Province Hospital  Nanjing 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